Regeneration and tolerance factor: A novel mediator of glioblastoma- associated immunosuppression

Patrick Roth*, Steffen Aulwurm, Isabella Gekel, Dagmar Beier, Roxanne G. Sperry, Michel Mittelbronn, Richard Meyermann, Kenneth D. Beaman, Michael Weller, Jörg Wishhusen

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)


Regeneration and tolerance factor (RTF) was originally identified in placenta where it is thought to be essential for fetal allograft survival. Here we report that RTF mRNA and protein are also expressed in human glioma cells in vitro and in vivo. Suppression of RTF expression by RNA interference promotes the lysis of glioma cells by natural killer (NK) and T cells in vitro. Moreover, RTF-depleted glioma cells are less tumorigenic than control cells in nude mice in vivo. Depletion of NK cells in these animals abolished this effect. RTF is thus a novel aberrantly expressed molecule which confers immune privilege to human malignant gliomas.

Original languageEnglish
Pages (from-to)3852-3858
Number of pages7
JournalCancer Research
Issue number7
Publication statusPublished - 1 Apr 2006
Externally publishedYes


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