Regeneration and tolerance factor: A novel mediator of glioblastoma- associated immunosuppression

Patrick Roth; Steffen Aulwurm; Isabella Gekel; Dagmar Beier; Roxanne G. Sperry; Michel Mittelbronn; Richard Meyermann; Kenneth D. Beaman; Michael Weller; Jörg Wishhusen

doi:10.1158/0008-5472.CAN-05-3062

Regeneration and tolerance factor: A novel mediator of glioblastoma- associated immunosuppression

Patrick Roth^*, Steffen Aulwurm, Isabella Gekel, Dagmar Beier, Roxanne G. Sperry, Michel Mittelbronn, Richard Meyermann, Kenneth D. Beaman, Michael Weller, Jörg Wishhusen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Abstract

Regeneration and tolerance factor (RTF) was originally identified in placenta where it is thought to be essential for fetal allograft survival. Here we report that RTF mRNA and protein are also expressed in human glioma cells in vitro and in vivo. Suppression of RTF expression by RNA interference promotes the lysis of glioma cells by natural killer (NK) and T cells in vitro. Moreover, RTF-depleted glioma cells are less tumorigenic than control cells in nude mice in vivo. Depletion of NK cells in these animals abolished this effect. RTF is thus a novel aberrantly expressed molecule which confers immune privilege to human malignant gliomas.

Original language	English
Pages (from-to)	3852-3858
Number of pages	7
Journal	Cancer Research
Volume	66
Issue number	7
DOIs	https://doi.org/10.1158/0008-5472.CAN-05-3062
Publication status	Published - 1 Apr 2006
Externally published	Yes

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10.1158/0008-5472.CAN-05-3062

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title = "Regeneration and tolerance factor: A novel mediator of glioblastoma- associated immunosuppression",

abstract = "Regeneration and tolerance factor (RTF) was originally identified in placenta where it is thought to be essential for fetal allograft survival. Here we report that RTF mRNA and protein are also expressed in human glioma cells in vitro and in vivo. Suppression of RTF expression by RNA interference promotes the lysis of glioma cells by natural killer (NK) and T cells in vitro. Moreover, RTF-depleted glioma cells are less tumorigenic than control cells in nude mice in vivo. Depletion of NK cells in these animals abolished this effect. RTF is thus a novel aberrantly expressed molecule which confers immune privilege to human malignant gliomas.",

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T2 - A novel mediator of glioblastoma- associated immunosuppression

AU - Roth, Patrick

AU - Aulwurm, Steffen

AU - Gekel, Isabella

AU - Beier, Dagmar

AU - Sperry, Roxanne G.

AU - Mittelbronn, Michel

AU - Meyermann, Richard

AU - Beaman, Kenneth D.

AU - Weller, Michael

AU - Wishhusen, Jörg

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Regeneration and tolerance factor (RTF) was originally identified in placenta where it is thought to be essential for fetal allograft survival. Here we report that RTF mRNA and protein are also expressed in human glioma cells in vitro and in vivo. Suppression of RTF expression by RNA interference promotes the lysis of glioma cells by natural killer (NK) and T cells in vitro. Moreover, RTF-depleted glioma cells are less tumorigenic than control cells in nude mice in vivo. Depletion of NK cells in these animals abolished this effect. RTF is thus a novel aberrantly expressed molecule which confers immune privilege to human malignant gliomas.

AB - Regeneration and tolerance factor (RTF) was originally identified in placenta where it is thought to be essential for fetal allograft survival. Here we report that RTF mRNA and protein are also expressed in human glioma cells in vitro and in vivo. Suppression of RTF expression by RNA interference promotes the lysis of glioma cells by natural killer (NK) and T cells in vitro. Moreover, RTF-depleted glioma cells are less tumorigenic than control cells in nude mice in vivo. Depletion of NK cells in these animals abolished this effect. RTF is thus a novel aberrantly expressed molecule which confers immune privilege to human malignant gliomas.

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SN - 0008-5472

VL - 66

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JO - Cancer Research

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Regeneration and tolerance factor: A novel mediator of glioblastoma- associated immunosuppression

Abstract

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