TY - JOUR
T1 - Reactive Oxygen Species
T2 - Involvement in T Cell Signaling and Metabolism
AU - Franchina, Davide G.
AU - Dostert, Catherine
AU - Brenner, Dirk
N1 - Funding Information:
We thank the Luxembourg National Research Fund (FNR) for support. D.B. is funded through the FNR-ATTRACT program and a FNR-CORE grant ( C15/BM/10355103 ). D.B. and D.G.F. are supported through the FNR-RIKEN and FNR-PRIDE funding schemes.
Funding Information:
We thank the Luxembourg National Research Fund (FNR) for support. D.B. is funded through the FNR-ATTRACT program (A14/BM/7632103) and the FNR-CORE (C15/BM/10355103) and the FNR-PRIDE (PRIDE/11012546/NEXTIMMUNE) funding schemes. D.B. and D.G.F. are supported through the FNR-RIKEN (TregBar/11228353) grant.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/6
Y1 - 2018/6
N2 - T cells are a central component of defenses against pathogens and tumors. Their effector functions are sustained by specific metabolic changes that occur upon activation, and these have been the focus of renewed interest. Energy production inevitably generates unwanted products, namely reactive oxygen species (ROS), which have long been known to trigger cell death. However, there is now evidence that ROS also act as intracellular signaling molecules both in steady-state and upon antigen recognition. The levels and localization of ROS contribute to the redox modeling of effector proteins and transcription factors, influencing the outcome of the T cell response. We discuss here how ROS can directly fine-tune metabolism and effector functions of T cells.
AB - T cells are a central component of defenses against pathogens and tumors. Their effector functions are sustained by specific metabolic changes that occur upon activation, and these have been the focus of renewed interest. Energy production inevitably generates unwanted products, namely reactive oxygen species (ROS), which have long been known to trigger cell death. However, there is now evidence that ROS also act as intracellular signaling molecules both in steady-state and upon antigen recognition. The levels and localization of ROS contribute to the redox modeling of effector proteins and transcription factors, influencing the outcome of the T cell response. We discuss here how ROS can directly fine-tune metabolism and effector functions of T cells.
KW - ROS
KW - T cell
KW - antioxidants
KW - glutathione
KW - metabolic reprogramming
UR - http://www.scopus.com/inward/record.url?scp=85041947374&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/29452982
U2 - 10.1016/j.it.2018.01.005
DO - 10.1016/j.it.2018.01.005
M3 - Review article
C2 - 29452982
AN - SCOPUS:85041947374
SN - 1471-4906
VL - 39
SP - 489
EP - 502
JO - Trends in Immunology
JF - Trends in Immunology
IS - 6
ER -