Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism

Davide G. Franchina, Catherine Dostert, Dirk Brenner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

219 Citations (Scopus)

Abstract

T cells are a central component of defenses against pathogens and tumors. Their effector functions are sustained by specific metabolic changes that occur upon activation, and these have been the focus of renewed interest. Energy production inevitably generates unwanted products, namely reactive oxygen species (ROS), which have long been known to trigger cell death. However, there is now evidence that ROS also act as intracellular signaling molecules both in steady-state and upon antigen recognition. The levels and localization of ROS contribute to the redox modeling of effector proteins and transcription factors, influencing the outcome of the T cell response. We discuss here how ROS can directly fine-tune metabolism and effector functions of T cells.

Original languageEnglish
Pages (from-to)489-502
Number of pages14
JournalTrends in Immunology
Volume39
Issue number6
DOIs
Publication statusPublished - Jun 2018

Keywords

  • ROS
  • T cell
  • antioxidants
  • glutathione
  • metabolic reprogramming

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