Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: Proposal of an unusual pathogenetic event and review of the literature

Jens Schittenhelm*, Rudi Beschorner, Tsambika Psaras, David Capper, Thomas Nägele, Richard Meyermann, Wolfgang Saeger, Jürgen Honegger, Michel Mittelbronn

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)

Abstract

Herein, we report on a lymphocytic hypophysitis related to a ruptured Rathke's cleft cyst which is not associated with pregnancy. A 45-year-old woman initially presented with headache and temporary double vision followed by amenorrhea. Preoperative imaging showed an intra- and suprasellar cystic mass. Complete resection of the tumor mass was performed via a transnasal, transseptal approach. Pathological examination displayed lymphocytic infiltrates within fibrotic tissue and residual pituitary cells accompanied by epithelial tissue of a Rathke's cleft cyst. The strongest inflammatory reaction was observed at the site of disrupture of the cyst integrity, suggesting that high protein levels from ruptured Rathke's cleft cyst might have triggered a lymphocytic hypophysitis. Our review of the literature provides further insights regarding the clinical behavior and different histological types of the lesions as well as the inflammatory changes that can occur in Rathke's cleft cysts.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalNeurosurgical Review
Volume31
Issue number2
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

Keywords

  • Cyst rupture
  • Hypophysitis
  • Pituitary gland
  • Rathke's cleft

Fingerprint

Dive into the research topics of 'Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: Proposal of an unusual pathogenetic event and review of the literature'. Together they form a unique fingerprint.

Cite this