Rare and new V3 loop variants in HIV-1-positive long-term non-progressors from Rwanda

François Roman; Etienne Karita; Alexia Monnet; Christine Lambert; Elodie Fontaine; Susan Allen; François Schneider; Robert Hemmer; Jean Claude Schmit; Vic Arendt

doi:10.1097/00002030-200209060-00017

Rare and new V3 loop variants in HIV-1-positive long-term non-progressors from Rwanda

François Roman^*
, Etienne Karita
, Alexia Monnet
, Christine Lambert
, Elodie Fontaine
, Susan Allen
, François Schneider
, Robert Hemmer
, Jean Claude Schmit
, Vic Arendt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

We identified uncommon amino acid substitutions in the V3 loop regions of HIV-1 strains infecting patients from Rwanda. Their frequency was greater in long-term non-progressors (LTNP) compared with late-stage patients (P=0.006), particularly in a sequence region that has crucial interactions with the cell surface, and is highly relevant for the host's immune response. These variants might reflect a viral response to a strong immune pressure, or represent attenuated HIV-1 strains infecting LTNP in Rwanda.

Original language	English
Pages (from-to)	1827-1829
Number of pages	3
Journal	AIDS
Volume	16
Issue number	13
DOIs	https://doi.org/10.1097/00002030-200209060-00017
Publication status	Published - 6 Sept 2002

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title = "Rare and new V3 loop variants in HIV-1-positive long-term non-progressors from Rwanda",

abstract = "We identified uncommon amino acid substitutions in the V3 loop regions of HIV-1 strains infecting patients from Rwanda. Their frequency was greater in long-term non-progressors (LTNP) compared with late-stage patients (P=0.006), particularly in a sequence region that has crucial interactions with the cell surface, and is highly relevant for the host's immune response. These variants might reflect a viral response to a strong immune pressure, or represent attenuated HIV-1 strains infecting LTNP in Rwanda.",

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T1 - Rare and new V3 loop variants in HIV-1-positive long-term non-progressors from Rwanda

AU - Roman, François

AU - Karita, Etienne

AU - Monnet, Alexia

AU - Lambert, Christine

AU - Fontaine, Elodie

AU - Allen, Susan

AU - Schneider, François

AU - Hemmer, Robert

AU - Schmit, Jean Claude

AU - Arendt, Vic

PY - 2002/9/6

Y1 - 2002/9/6

N2 - We identified uncommon amino acid substitutions in the V3 loop regions of HIV-1 strains infecting patients from Rwanda. Their frequency was greater in long-term non-progressors (LTNP) compared with late-stage patients (P=0.006), particularly in a sequence region that has crucial interactions with the cell surface, and is highly relevant for the host's immune response. These variants might reflect a viral response to a strong immune pressure, or represent attenuated HIV-1 strains infecting LTNP in Rwanda.

AB - We identified uncommon amino acid substitutions in the V3 loop regions of HIV-1 strains infecting patients from Rwanda. Their frequency was greater in long-term non-progressors (LTNP) compared with late-stage patients (P=0.006), particularly in a sequence region that has crucial interactions with the cell surface, and is highly relevant for the host's immune response. These variants might reflect a viral response to a strong immune pressure, or represent attenuated HIV-1 strains infecting LTNP in Rwanda.

UR - https://www.scopus.com/pages/publications/18644375237

U2 - 10.1097/00002030-200209060-00017

DO - 10.1097/00002030-200209060-00017

M3 - Article

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AN - SCOPUS:18644375237

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VL - 16

SP - 1827

EP - 1829

JO - AIDS

JF - AIDS

IS - 13

ER -

Rare and new V3 loop variants in HIV-1-positive long-term non-progressors from Rwanda

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