Rare and new V3 loop variants in HIV-1-positive long-term non-progressors from Rwanda

François Roman*, Etienne Karita, Alexia Monnet, Christine Lambert, Elodie Fontaine, Susan Allen, François Schneider, Robert Hemmer, Jean Claude Schmit, Vic Arendt

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    5 Citations (Scopus)

    Abstract

    We identified uncommon amino acid substitutions in the V3 loop regions of HIV-1 strains infecting patients from Rwanda. Their frequency was greater in long-term non-progressors (LTNP) compared with late-stage patients (P=0.006), particularly in a sequence region that has crucial interactions with the cell surface, and is highly relevant for the host's immune response. These variants might reflect a viral response to a strong immune pressure, or represent attenuated HIV-1 strains infecting LTNP in Rwanda.

    Original languageEnglish
    Pages (from-to)1827-1829
    Number of pages3
    JournalAIDS
    Volume16
    Issue number13
    DOIs
    Publication statusPublished - 6 Sep 2002

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