Abstract
We identified uncommon amino acid substitutions in the V3 loop regions of HIV-1 strains infecting patients from Rwanda. Their frequency was greater in long-term non-progressors (LTNP) compared with late-stage patients (P=0.006), particularly in a sequence region that has crucial interactions with the cell surface, and is highly relevant for the host's immune response. These variants might reflect a viral response to a strong immune pressure, or represent attenuated HIV-1 strains infecting LTNP in Rwanda.
Original language | English |
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Pages (from-to) | 1827-1829 |
Number of pages | 3 |
Journal | AIDS |
Volume | 16 |
Issue number | 13 |
DOIs | |
Publication status | Published - 6 Sept 2002 |