Réponse individuelle aux radiations ionisantes: quel(s) test(s) prédictif(s) choisir?

Translated title of the contribution: Individual response to ionising radiation: What predictive assay(s) to choose?

Adeline Granzotto, Aurélie Joubert, Muriel Viau, Clément Devic, Mira Maalouf, Charles Thomas, Guillaume Vogin, Karim Malek, Catherine Colin, Jacques Balosso, Nicolas Foray*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Individual response to ionizing radiation is an important information required to apply an efficient radiotherapy treatment against tumour and to avoid any adverse effects in normal tissues. In 1981, Fertil and Malaise have demonstrated that the post-irradiation local tumor control determined in vivo is correlated with clonogenic cell survival assessed in vitro. Furthermore, these authors have reminded the relevance of the concept of intrinsic radiosensitivity that is specific to each individual organ (Fertil and Malaise, 1981) [1]. To date, since clonogenicity assays are too time-consuming and do not provide any other molecular information, a plethora of research groups have attempted to determine the molecular bases of intrinsic radiosensitivity in order to propose reliable and faster predictive assays. To this aim, several approaches have been developed. Notably, the recent revolution in genomic and proteomic technologies is providing a considerable number of data but their link with radiosensitivity still remains to be elucidated. On another hand, the systematic screening of some candidate genes potentially involved in the radiation response is highlighting the complexity of the molecular and cellular mechanisms of DNA damage sensoring and signalling and shows that an abnormal radiation response is not necessarily due to the impairment of one single protein. Finally, more modest approaches consisting in focusing some specific functions of DNA repair seem to provide more reliable clues to predict over-acute reactions caused by radiotherapy. In this review, we endeavoured to analyse the contributions of these major approaches to predict human radiosensitivity.

Translated title of the contributionIndividual response to ionising radiation: What predictive assay(s) to choose?
Original languageFrench
Pages (from-to)140-157
Number of pages18
JournalComptes Rendus - Biologies
Volume334
Issue number2
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes

Keywords

  • DNA repair
  • Gene expression
  • Gene functions
  • Mutations
  • Predictive assays
  • Radiations
  • Radiosensitivity

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