TY - JOUR
T1 - Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore
AU - Sommer, Peter
AU - Nehrbass, Ulf
N1 - Funding Information:
We apologise to all colleagues whose original work could not be cited owing to space limitations and wish to thank Olivier Gadal, Vincent Galy and Annette Boese for stimulating discussions and critical reading of the manuscript. P Sommer is grateful for a fellowship from SIDACTION/ECS.
PY - 2005/6
Y1 - 2005/6
N2 - The spatial separation of nuclear transcription and cytoplasmic translation in eukaryotic cells implies that mRNAs have to travel. On their journey, proteins involved in the various steps of transcript formation, processing and transport dynamically interact with mRNAs to form diverse messenger ribonucleoprotein complexes (mRNPs). Increasing evidence indicates that the protein complexes involved in distinct phases of manufacturing a bona fide mRNA in the nucleus are tightly coupled. Moreover, the recent demonstration that active genes migrate into preassembled, shared nuclear sub-compartments suggests that mRNAs are churned out in large 'transcription factories' with distinct but interconnected divisions. Nuclear factors have now been identified that specifically control the quality of mRNAs without affecting mRNP biogenesis or export.
AB - The spatial separation of nuclear transcription and cytoplasmic translation in eukaryotic cells implies that mRNAs have to travel. On their journey, proteins involved in the various steps of transcript formation, processing and transport dynamically interact with mRNAs to form diverse messenger ribonucleoprotein complexes (mRNPs). Increasing evidence indicates that the protein complexes involved in distinct phases of manufacturing a bona fide mRNA in the nucleus are tightly coupled. Moreover, the recent demonstration that active genes migrate into preassembled, shared nuclear sub-compartments suggests that mRNAs are churned out in large 'transcription factories' with distinct but interconnected divisions. Nuclear factors have now been identified that specifically control the quality of mRNAs without affecting mRNP biogenesis or export.
UR - http://www.scopus.com/inward/record.url?scp=19344363599&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2005.04.007
DO - 10.1016/j.ceb.2005.04.007
M3 - Review article
C2 - 15901500
AN - SCOPUS:19344363599
SN - 0955-0674
VL - 17
SP - 294
EP - 301
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -