TY - JOUR
T1 - Public health burden of pre-diabetes and diabetes in Luxembourg
T2 - Finding from the 2013-2015 European Health Examination Survey
AU - Bocquet, Valéry
AU - Ruiz-Castell, Maria
AU - De Beaufort, Carine
AU - Barré, Jessica
AU - De Rekeneire, Nathalie
AU - Michel, Georges
AU - Donahue, Richard P.
AU - Kuemmerle, Andrea
AU - Stranges, Saverio
N1 - Funding Information:
Funding This study was funded by the Directorate and Ministry of Health and the Luxembourg Institute of Health.
Publisher Copyright:
© Author(s) (or their employer(s)) 2019.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective The aim of this study was to determine the burden and risk factors of prediabetes and diabetes in the general adult population of Luxembourg. Design Cross-sectional survey between 2013 and 2015. Setting Data were collected as part of the European Health Examination Survey in Luxembourg (EHES-LUX). Participants 1451 individuals were recruited in a random sample of the 25-64-year-old population of Luxembourg. Outcomes Diabetes was defined by a glycaemic biomarker (fasting plasma glucose (FPG) ≥7.0 mmol/L), self-reported medication and medical diagnosis; prediabetes by a glycaemic biomarker (FPG 5.6-6.9 mmol/L), no self-reported medication and no medical diagnosis. Undiagnosed diabetes was defined only from the glycaemic biomarker; the difference between total and undiagnosed diabetes was defined as diagnosed diabetes. Odds of diabetes and prediabetes as well as associated risk factors were estimated. Results The weighted prevalence of prediabetes and diabetes was 25.6% and 6.5%, respectively. Nearly 4.8% (men: 5.8%; women: 3.8%) were diagnosed diabetes and 1.7% (men: 2.6%; women: 0.7%) were undiagnosed diabetes. The multivariable-adjusted OR (MVOR) for diabetes risk were: Age 1.05 (95% CI 1.01 to 1.09), family history of diabetes 3.24 (1.95-5.38), abdominal obesity 2.63 (1.53-4.52), hypertension 3.18 (1.76-5.72), one-unit increase of triglycerides 1.16 (1.10-1.22) and total cholesterol 0.74 (0.64-0.86). The MVOR for prediabetes risk were: Age 1.04 (95% CI 1.02 to 1.06), male sex 1.84 (1.30-2.60), moderate alcohol consumption 1.38 (1.01-1.89), family history of diabetes 1.52 (1.13-2.05), abdominal obesity 1.44 (1.06-1.97), second-generation immigrants 0.61 (0.39-0.95) and a one-unit increase of serum high-density lipoprotein cholesterol 0.70 (0.54-0.90). Conclusions In Luxembourg, an unexpectedly high number of adults may be affected by prediabetes and diabetes. Therefore, these conditions should be addressed as a public health priority for the country, requiring measures for enhanced detection and surveillance, which are currently lacking, especially in primary care settings.
AB - Objective The aim of this study was to determine the burden and risk factors of prediabetes and diabetes in the general adult population of Luxembourg. Design Cross-sectional survey between 2013 and 2015. Setting Data were collected as part of the European Health Examination Survey in Luxembourg (EHES-LUX). Participants 1451 individuals were recruited in a random sample of the 25-64-year-old population of Luxembourg. Outcomes Diabetes was defined by a glycaemic biomarker (fasting plasma glucose (FPG) ≥7.0 mmol/L), self-reported medication and medical diagnosis; prediabetes by a glycaemic biomarker (FPG 5.6-6.9 mmol/L), no self-reported medication and no medical diagnosis. Undiagnosed diabetes was defined only from the glycaemic biomarker; the difference between total and undiagnosed diabetes was defined as diagnosed diabetes. Odds of diabetes and prediabetes as well as associated risk factors were estimated. Results The weighted prevalence of prediabetes and diabetes was 25.6% and 6.5%, respectively. Nearly 4.8% (men: 5.8%; women: 3.8%) were diagnosed diabetes and 1.7% (men: 2.6%; women: 0.7%) were undiagnosed diabetes. The multivariable-adjusted OR (MVOR) for diabetes risk were: Age 1.05 (95% CI 1.01 to 1.09), family history of diabetes 3.24 (1.95-5.38), abdominal obesity 2.63 (1.53-4.52), hypertension 3.18 (1.76-5.72), one-unit increase of triglycerides 1.16 (1.10-1.22) and total cholesterol 0.74 (0.64-0.86). The MVOR for prediabetes risk were: Age 1.04 (95% CI 1.02 to 1.06), male sex 1.84 (1.30-2.60), moderate alcohol consumption 1.38 (1.01-1.89), family history of diabetes 1.52 (1.13-2.05), abdominal obesity 1.44 (1.06-1.97), second-generation immigrants 0.61 (0.39-0.95) and a one-unit increase of serum high-density lipoprotein cholesterol 0.70 (0.54-0.90). Conclusions In Luxembourg, an unexpectedly high number of adults may be affected by prediabetes and diabetes. Therefore, these conditions should be addressed as a public health priority for the country, requiring measures for enhanced detection and surveillance, which are currently lacking, especially in primary care settings.
KW - epidemiology
KW - european health examination survey
KW - general diabetes
KW - prevalence
KW - public health
UR - http://www.scopus.com/inward/record.url?scp=85060391657&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/30670502
U2 - 10.1136/bmjopen-2018-022206
DO - 10.1136/bmjopen-2018-022206
M3 - Article
C2 - 30670502
AN - SCOPUS:85060391657
SN - 2044-6055
VL - 9
JO - BMJ Open
JF - BMJ Open
IS - 1
M1 - e022206
ER -