Proton therapy in soft tissue and bone sarcomas

Juliette Thariat*, Thomas Tessonnier, Sylvie Bonvalot, Delphine Lerouge, Hamid Mammar, Stephanie Bolle, Audrey Claren, Florence Duffaud, Claire Alapetite, Guillaume Vogin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Sarcomas are a common type of tumor within the pediatric population. The utilization of proton therapy as a primary attribute the ability to spare adjacent healthy tissue, therefore, proton therapy has become a preferential indication in pediatrics compared to other photon irradiation modalities. Proton therapy is also a proven and historically validated irradiation technique in the treatment of chondrosarcomas and chordomas of the skull base and spine. Additionally, proton therapy can potentially limit irradiated healthy tissue volumes in adults and limit the risk of acute and late toxicities. The evaluation of the effectiveness of proton therapy in sarcomas is underway in many clinical situations in prospective trials, some of which are randomized.

Original languageEnglish
Pages (from-to)830-838
Number of pages9
JournalBulletin du Cancer
Issue number9
Publication statusPublished - Sept 2018
Externally publishedYes


  • Hadrontherapy
  • Level of evidence
  • Proton therapy
  • Sarcoma


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