Proteomics and drug discovery in cancer

Matheus H. Dias; Eduardo S. Kitano; André Zelanis; Leo K. Iwai

doi:10.1016/j.drudis.2015.10.004

Proteomics and drug discovery in cancer

Matheus H. Dias, Eduardo S. Kitano, André Zelanis, Leo K. Iwai^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

Proteomics has emerged as an invaluable tool in the quest to unravel the biochemical changes that give rise to the hallmarks of cancer. In this review, we present the advances and challenges facing proteomics technology as applied to cancer research, and address how the information gathered so far has helped to enhance understanding of the mechanisms underlying the disease and contributed to the discovery of biomarkers and new drug targets. We conclude by presenting a perspective on how proteomics could be applied in the future to determine prognostic biomarkers and direct strategies for effective cancer treatment.

Original language	English
Pages (from-to)	264-277
Number of pages	14
Journal	Drug Discovery Today
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.drudis.2015.10.004
Publication status	Published - 2016
Externally published	Yes

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10.1016/j.drudis.2015.10.004

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title = "Proteomics and drug discovery in cancer",

abstract = "Proteomics has emerged as an invaluable tool in the quest to unravel the biochemical changes that give rise to the hallmarks of cancer. In this review, we present the advances and challenges facing proteomics technology as applied to cancer research, and address how the information gathered so far has helped to enhance understanding of the mechanisms underlying the disease and contributed to the discovery of biomarkers and new drug targets. We conclude by presenting a perspective on how proteomics could be applied in the future to determine prognostic biomarkers and direct strategies for effective cancer treatment.",

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AU - Kitano, Eduardo S.

AU - Zelanis, André

AU - Iwai, Leo K.

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AB - Proteomics has emerged as an invaluable tool in the quest to unravel the biochemical changes that give rise to the hallmarks of cancer. In this review, we present the advances and challenges facing proteomics technology as applied to cancer research, and address how the information gathered so far has helped to enhance understanding of the mechanisms underlying the disease and contributed to the discovery of biomarkers and new drug targets. We conclude by presenting a perspective on how proteomics could be applied in the future to determine prognostic biomarkers and direct strategies for effective cancer treatment.

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DO - 10.1016/j.drudis.2015.10.004

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Proteomics and drug discovery in cancer

Abstract

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