Prolonged clinically asymptomatic evolution after HIV‐1 infection is marked by the absence of complement C4 null alleles at the MHC

F. HENTGES*, A. HOFFMANN, F. OLIVEIRA DE ARAUJO, R. HEMMER

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

The length of time after which persons infected with HIV‐1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV‐1‐infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV‐1‐infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleles.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalClinical and Experimental Immunology
Volume88
Issue number2
DOIs
Publication statusPublished - May 1992
Externally publishedYes

Keywords

  • C4 null alleles
  • HIV‐1
  • asymptomatic period

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