The length of time after which persons infected with HIV‐1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV‐1‐infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV‐1‐infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleles.
|Number of pages||6|
|Journal||Clinical and Experimental Immunology|
|Publication status||Published - May 1992|
- C4 null alleles
- asymptomatic period