TY - JOUR
T1 - Progressive sleep 'destructuring' in Parkinson's disease. A polysomnographic study in 46 patients
AU - Diederich, Nico J.
AU - Vaillant, Michel
AU - Mancuso, Giovanna
AU - Lyen, Peter
AU - Tiete, Jo
PY - 2005/7
Y1 - 2005/7
N2 - Background: Sleep abnormalities in Parkinson's disease (PD) are frequent, but it is unknown whether or not there is progressive loss of physiological sleep architecture or what the causes could be. Methods: Retrospective review of medical records and polysomnographic data from 46 non-demented PD patients. Results: Sleep latency was correlated with disease duration (F1,44=4.87, P=0.03). Total sleep time (F1,44=8.54, P=0.005), deep sleep time (F1,44=4.06, P=0.05), REM sleep time (F1,44=9.15, P=0.004) and sleep efficiency (SE) (F1,44=10.20, P=0.003) were inversely correlated with disease duration. The same sleep parameters were independent from the degree of motor impairment, dosage of the dopaminergic medications, and age. Subjective sleep complaints could only partially predict abnormalities in polysomnographic (PSG) studies. Conclusion: In PD nocturnal sleep 'destructuring' is linked to disease duration and evolves independently from other major disease parameters.
AB - Background: Sleep abnormalities in Parkinson's disease (PD) are frequent, but it is unknown whether or not there is progressive loss of physiological sleep architecture or what the causes could be. Methods: Retrospective review of medical records and polysomnographic data from 46 non-demented PD patients. Results: Sleep latency was correlated with disease duration (F1,44=4.87, P=0.03). Total sleep time (F1,44=8.54, P=0.005), deep sleep time (F1,44=4.06, P=0.05), REM sleep time (F1,44=9.15, P=0.004) and sleep efficiency (SE) (F1,44=10.20, P=0.003) were inversely correlated with disease duration. The same sleep parameters were independent from the degree of motor impairment, dosage of the dopaminergic medications, and age. Subjective sleep complaints could only partially predict abnormalities in polysomnographic (PSG) studies. Conclusion: In PD nocturnal sleep 'destructuring' is linked to disease duration and evolves independently from other major disease parameters.
KW - Excessive daytime sleepiness
KW - Parkinson's disease
KW - Polysomnography
KW - REM sleep behavior disorder
KW - Sleep architecture
UR - http://www.scopus.com/inward/record.url?scp=20944438110&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2005.03.011
DO - 10.1016/j.sleep.2005.03.011
M3 - Article
C2 - 15946897
AN - SCOPUS:20944438110
SN - 1389-9457
VL - 6
SP - 313
EP - 318
JO - Sleep Medicine
JF - Sleep Medicine
IS - 4
ER -