Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders

Stefka Krumova*, Ivona Andonova, Radostina Stefanova, Polina Miteva, Galina Nenkova, Judith M. Hübschen

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


Primate erythroparvovirus 1, commonly referred to as Parvovirus B19 (B19V), is a DNA virus that normally results in a mild childhood infection called “erythema infectiosum”. Besides respiratory spread, B19V can also be transmitted through transfusions, which may result in persistent anemia in immunodeficient hosts. Dialysis patients often face acute or chronic anemia after infection with B19V. Here, we describe the laboratory investigation of 21 patients with hematological disorders for B19V infections. B19V DNA was detected in 13 (62%) of them, with specific IgM antibodies in three of the DNA positives. All 13 patients received treatment and were laboratory-monitored over a period of one year. In only two patients (a 14-year-old child with a kidney transplantation and a 39-year-old patient with aplastic anemia), markers of recent B19V infection were still detectable in follow-up samples. For four B19V DNA positive samples, short sequences could be obtained, which clustered with genotype 1a reference strains. Our findings suggest that all cases of hematological disorders should be examined for specific B19V antibodies and DNA for accurate diagnosis and appropriate patient management.

Original languageEnglish
Article number497
Issue number5
Publication statusPublished - 21 Apr 2022


  • anemia
  • IgM antibodies
  • kidney recipients
  • Parvovirus B19 (B19V)
  • viral DNA


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