TY - JOUR
T1 - Prevention of infective endocarditis and bacterial resistance to antibiotics
T2 - A brief review
AU - Loyola-Rodriguez, Juan Pablo
AU - Franco-Miranda, Alexandre
AU - Loyola-Leyva, Alejandra
AU - Perez-Elizalde, Bulfrano
AU - Contreras-Palma, Guillermo
AU - Sanchez-Adame, Oscar
N1 - Publisher Copyright:
© 2019 Special Care Dentistry Association and Wiley Periodicals, Inc.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - The purpose of this statement is to debate the recommendations of the American Heart Association (AHA) for the prevention of infective endocarditis through an antibiotic prophylaxis protocol and its relation with bacterial resistance to antibiotics. Since dental infections involve biofilms that include several bacterial species (Gram-negative and Gram-positive), it is essential, from the dental point of view, to consider the frequency, magnitude, and duration of bacteremia associated with active dental infections before applying antibiotic prophylaxis. The actual guidelines for antibiotic prophylaxis should be revised according to recent evidence of bacterial resistance. Amoxicillin/clavulanic acid and moxifloxacin should be considered due to their effectiveness against bacteria associated with oral, GU, and GI infections and the low rates of antibiotic resistance associated with these antibiotics, instead of the actual protocol, which includes amoxicillin (2 g) or clindamycin (600 mg) administered an hour before the dental procedures. The breaking point to test the antibiotic bacterial resistance (ABR) had a wide range in the different studies that were analyzed, which could explain the widely varied ABR percentages reported for the various antibiotics used for antibiotic prophylaxis.
AB - The purpose of this statement is to debate the recommendations of the American Heart Association (AHA) for the prevention of infective endocarditis through an antibiotic prophylaxis protocol and its relation with bacterial resistance to antibiotics. Since dental infections involve biofilms that include several bacterial species (Gram-negative and Gram-positive), it is essential, from the dental point of view, to consider the frequency, magnitude, and duration of bacteremia associated with active dental infections before applying antibiotic prophylaxis. The actual guidelines for antibiotic prophylaxis should be revised according to recent evidence of bacterial resistance. Amoxicillin/clavulanic acid and moxifloxacin should be considered due to their effectiveness against bacteria associated with oral, GU, and GI infections and the low rates of antibiotic resistance associated with these antibiotics, instead of the actual protocol, which includes amoxicillin (2 g) or clindamycin (600 mg) administered an hour before the dental procedures. The breaking point to test the antibiotic bacterial resistance (ABR) had a wide range in the different studies that were analyzed, which could explain the widely varied ABR percentages reported for the various antibiotics used for antibiotic prophylaxis.
KW - infection control
KW - microbiology
KW - public health dentistry
UR - http://www.scopus.com/inward/record.url?scp=85071614850&partnerID=8YFLogxK
U2 - 10.1111/scd.12415
DO - 10.1111/scd.12415
M3 - Review article
C2 - 31464005
AN - SCOPUS:85071614850
SN - 0275-1879
VL - 39
SP - 603
EP - 609
JO - Special Care in Dentistry
JF - Special Care in Dentistry
IS - 6
ER -