TY - JOUR
T1 - Preventing regrettable substitutions
T2 - a proposal for a tiered testing approach for BPA alternatives under the PARC initiative
AU - Aiello-Holden, Kiara
AU - Bartmann, Kristina
AU - Buratti, Franca Maria
AU - Cabaton, Nicolas J.
AU - Coppola, Lucia
AU - Corsini, Emanuela
AU - De la Vieja, Antonio
AU - Dirven, Hubert
AU - Dusinska, Maria
AU - El Yamani, Naouale
AU - Franko, Nina
AU - Gostner, Johanna M.
AU - Grova, Nathalie
AU - Gütter, Louise
AU - Iglesias-Hernández, Patricia
AU - Iulini, Martina
AU - Kodila, Anja
AU - Kohl, Yvonne
AU - Lori, Gabriele
AU - Louro, Henriqueta
AU - Marcon, Francesca
AU - Mhaouty-Kodja, Sakina
AU - Mposhi, Archibold
AU - Naulé, Lydie
AU - Palleschi, Simonetta
AU - Rossi, Barbara
AU - Rundén-Pran, Elise
AU - Salani, Francesca
AU - Santori, Nicoletta
AU - Silva, Maria João
AU - Dolenc, Marija Sollner
AU - Testai, Emanuela
AU - Torres-Ruiz, Mónica
AU - Turner, Jonathan
AU - Viguié, Catherine
AU - Zalko, Daniel
AU - Tait, Sabrina
N1 - Copyright © 2026 Aiello-Holden, Bartmann, Buratti, Cabaton, Coppola, Corsini, De la Vieja, Dirven, Dusinska, El Yamani, Franko, Gostner, Grova, Gütter, Iglesias-Hernández, Iulini, Kodila, Kohl, Lori, Louro, Marcon, Mhaouty-Kodja, Mposhi, Naulé, Palleschi, Rossi, Rundén-Pran, Salani, Santori, Silva, Dolenc, Testai, Torres-Ruiz, Turner, Viguié, Zalko and Tait.
PY - 2026/7/10
Y1 - 2026/7/10
N2 - Bisphenol A (BPA) alternatives are increasingly used in the manufacture of industrial and consumer products, following regulatory restrictions on BPA. However, insufficient safety data on these substitutes raise concern as regards potential regrettable substitutions. Under the EU Partnership for the Assessment of Risks from Chemicals (PARC), Work Package 5 (WP5) addresses this challenge by applying a human-relevant tiered hazard assessment strategy grounded on OECD test guidelines as first tier and expanding the battery to include NAMs (New Approach Methodologies). Eight BPA alternatives were prioritized for studies addressing key toxicological endpoints, namely, endocrine disruption (ED), developmental neurotoxicity (DNT), immunotoxicity, genotoxicity and carcinogenicity and metabolic fate examination (detoxification vs. potential bioactivation), to enable early identification of biological activity and support cross-endpoint prioritization. This manuscript describes the structure and implementation of the testing framework. This integrated testing strategy proposes a structured approach to identify substances of potential concern, guide targeted higher-tier studies, and support regulatory prioritization. PARC WP5 framework is testing whether coordinated NAM-based methods may contribute to next-generation risk assessment and help prevent regrettable substitutions among BPA alternatives for rapid regulatory adoption. Detailed experimental results will be reported separately upon completion of the project.
AB - Bisphenol A (BPA) alternatives are increasingly used in the manufacture of industrial and consumer products, following regulatory restrictions on BPA. However, insufficient safety data on these substitutes raise concern as regards potential regrettable substitutions. Under the EU Partnership for the Assessment of Risks from Chemicals (PARC), Work Package 5 (WP5) addresses this challenge by applying a human-relevant tiered hazard assessment strategy grounded on OECD test guidelines as first tier and expanding the battery to include NAMs (New Approach Methodologies). Eight BPA alternatives were prioritized for studies addressing key toxicological endpoints, namely, endocrine disruption (ED), developmental neurotoxicity (DNT), immunotoxicity, genotoxicity and carcinogenicity and metabolic fate examination (detoxification vs. potential bioactivation), to enable early identification of biological activity and support cross-endpoint prioritization. This manuscript describes the structure and implementation of the testing framework. This integrated testing strategy proposes a structured approach to identify substances of potential concern, guide targeted higher-tier studies, and support regulatory prioritization. PARC WP5 framework is testing whether coordinated NAM-based methods may contribute to next-generation risk assessment and help prevent regrettable substitutions among BPA alternatives for rapid regulatory adoption. Detailed experimental results will be reported separately upon completion of the project.
KW - bisphenol a alternatives
KW - carcinogenicity
KW - developmental neurotoxicity (DNT)
KW - endocrine disruption (ED)
KW - human hazard assessment
KW - immunotoxicity
KW - metabolism
KW - new approach methodologies (NAMs)
UR - https://www.scopus.com/pages/publications/105046505735
U2 - 10.3389/ftox.2026.1815869
DO - 10.3389/ftox.2026.1815869
M3 - Article
C2 - 42488797
AN - SCOPUS:105046505735
SN - 2673-3080
VL - 8
JO - Frontiers in Toxicology
JF - Frontiers in Toxicology
M1 - 1815869
ER -