@article{64b575716dfd4786b27c6966785f88c2,
title = "Prevalence of sexual dimorphism in mammalian phenotypic traits",
abstract = "The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.",
author = "Karp, \{Natasha A.\} and Jeremy Mason and Beaudet, \{Arthur L.\} and Yoav Benjamini and Lynette Bower and Braun, \{Robert E.\} and Brown, \{Steve D.M.\} and Chesler, \{Elissa J.\} and Dickinson, \{Mary E.\} and Flenniken, \{Ann M.\} and Helmut Fuchs and \{de Angelis\}, \{Martin Hrabe\} and Xiang Gao and Shiying Guo and Simon Greenaway and Ruth Heller and Yann Herault and Justice, \{Monica J.\} and Natalja Kurbatova and Lelliott, \{Christopher J.\} and Lloyd, \{K. C.Kent\} and Mallon, \{Ann Marie\} and Mank, \{Judith E.\} and Hiroshi Masuya and Colin McKerlie and Meehan, \{Terrence F.\} and Mott, \{Richard F.\} and Murray, \{Stephen A.\} and Helen Parkinson and Ramiro Ramirez-Solis and Luis Santos and Seavitt, \{John R.\} and Damian Smedley and Tania Sorg and Speak, \{Anneliese O.\} and Steel, \{Karen P.\} and Svenson, \{Karen L.\} and Shigeharu Wakana and David West and Sara Wells and Henrik Westerberg and Shay Yaacoby and White, \{Jacqueline K.\} and Yuichi Obata and Tomohiro Suzuki and Masaru Tamura and Hideki Kaneda and Tamio Furuse and Kimio Kobayashi and Markus Ollert and \{The International Mouse Phenotyping Consortium\}",
note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = jun,
day = "26",
doi = "10.1038/ncomms15475",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Research",
}