Prevalence of sexual dimorphism in mammalian phenotypic traits

The International Mouse Phenotyping Consortium

Research output: Contribution to journalArticleResearchpeer-review

125 Citations (Scopus)

Abstract

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.

Original languageEnglish
Article number15475
JournalNature Communications
Volume8
DOIs
Publication statusPublished - 26 Jun 2017

Fingerprint

Dive into the research topics of 'Prevalence of sexual dimorphism in mammalian phenotypic traits'. Together they form a unique fingerprint.

Cite this