@article{64b575716dfd4786b27c6966785f88c2,
title = "Prevalence of sexual dimorphism in mammalian phenotypic traits",
abstract = "The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.",
author = "Karp, {Natasha A.} and Jeremy Mason and Beaudet, {Arthur L.} and Yoav Benjamini and Lynette Bower and Braun, {Robert E.} and Brown, {Steve D.M.} and Chesler, {Elissa J.} and Dickinson, {Mary E.} and Flenniken, {Ann M.} and Helmut Fuchs and {de Angelis}, {Martin Hrabe} and Xiang Gao and Shiying Guo and Simon Greenaway and Ruth Heller and Yann Herault and Justice, {Monica J.} and Natalja Kurbatova and Lelliott, {Christopher J.} and Lloyd, {K. C.Kent} and Mallon, {Ann Marie} and Mank, {Judith E.} and Hiroshi Masuya and Colin McKerlie and Meehan, {Terrence F.} and Mott, {Richard F.} and Murray, {Stephen A.} and Helen Parkinson and Ramiro Ramirez-Solis and Luis Santos and Seavitt, {John R.} and Damian Smedley and Tania Sorg and Speak, {Anneliese O.} and Steel, {Karen P.} and Svenson, {Karen L.} and Shigeharu Wakana and David West and Sara Wells and Henrik Westerberg and Shay Yaacoby and White, {Jacqueline K.} and Yuichi Obata and Tomohiro Suzuki and Masaru Tamura and Hideki Kaneda and Tamio Furuse and Kimio Kobayashi and Markus Ollert and {The International Mouse Phenotyping Consortium}",
note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = jun,
day = "26",
doi = "10.1038/ncomms15475",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}