TY - JOUR
T1 - Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
AU - Hughes, David J.
AU - Duarte-Salles, Talita
AU - Hybsier, Sandra
AU - Trichopoulou, Antonia
AU - Stepien, Magdalena
AU - Aleksandrova, Krasimira
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Affret, Aurélie
AU - Fagherazzi, Guy
AU - Boutron-Ruault, Marie Christine
AU - Katzke, Verena
AU - Kaaks, Rudolf
AU - Boeing, Heiner
AU - Bamia, Christina
AU - Lagiou, Pagona
AU - Peppa, Eleni
AU - Palli, Domenico
AU - Krogh, Vittorio
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Bueno-De-Mesquita, Hendrik Bastiaan
AU - Peeters, Petra H.
AU - Engeset, Dagrun
AU - Weiderpass, Elisabete
AU - Lasheras, Cristina
AU - Agudo, Antonio
AU - Sánchez, Maria José
AU - Navarro, Carmen
AU - Ardanaz, Eva
AU - Dorronsoro, Miren
AU - Hemmingsson, Oskar
AU - Wareham, Nicholas J.
AU - Khaw, Kay Tee
AU - Bradbury, Kathryn E.
AU - Cross, Amanda J.
AU - Gunter, Marc
AU - Riboli, Elio
AU - Romieu, Isabelle
AU - Schomburg, Lutz
AU - Jenab, Mazda
N1 - Publisher Copyright:
© 2016 American Society for Nutrition.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract. Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Design: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression. Results: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-mg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend ≤ 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63). Conclusion: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
AB - Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract. Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Design: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression. Results: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-mg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend ≤ 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63). Conclusion: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
KW - Hepatobiliary cancer
KW - Hepatocellular carcinoma
KW - Liver cancer
KW - Prospective cohort
KW - Selenium
KW - Selenium status
KW - Selenoprotein P
UR - http://www.scopus.com/inward/record.url?scp=84980322411&partnerID=8YFLogxK
U2 - 10.3945/ajcn.116.131672
DO - 10.3945/ajcn.116.131672
M3 - Article
C2 - 27357089
AN - SCOPUS:84980322411
SN - 0002-9165
VL - 104
SP - 406
EP - 414
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -