TY - JOUR
T1 - Prediagnostic body size and breast cancer survival in the E3N cohort study
AU - His, Mathilde
AU - Fagherazzi, Guy
AU - Mesrine, Sylvie
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Françoise
AU - Dossus, Laure
N1 - Publisher Copyright:
© 2016 UICC.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Obesity has been associated with poor breast cancer prognosis, however most studies have focused on body mass index (BMI) and few have considered the distribution of adipose tissue. We investigated associations between prediagnostic adiposity and breast cancer survival, considering BMI, waist and hip circumferences (WC and HC), and waist-to-hip ratio (WHR). Analyses included 3,006 women from the French E3N prospective cohort study diagnosed with primary invasive breast cancer between 1995 and 2008. We investigated overall, breast cancer-specific, and disease-free survival, overall and according to stage, menopausal and hormonal status and year of diagnosis, using Cox proportional hazard models adjusted for tumor characteristics and lifestyle risk factors. Women with a prediagnostic HC > 100 cm were at increased risk of death from all causes (hazard ratio (HR)>100vs < 95 cm = 1.38, 95% Confidence Interval (CI) = 1.02-1.86, Ptrend = 0.02) and from breast cancer (HR>100vs < 95 cm = 1.50, CI = 1.03-2.17, Ptrend = 0.03), and of second invasive cancer event (HR>100vs < 95 cm = 1.36, CI = 1.11-1.67, Ptrend = 0.002), compared to those with HC <95 cm. Associations were stronger after adjustment for BMI. BMI, WC and WHR were not associated with survival after breast cancer. Our study underlines the importance of going beyond BMI when studying the association between adiposity and breast cancer survival. Further studies should be conducted to confirm our results on hip circumference.
AB - Obesity has been associated with poor breast cancer prognosis, however most studies have focused on body mass index (BMI) and few have considered the distribution of adipose tissue. We investigated associations between prediagnostic adiposity and breast cancer survival, considering BMI, waist and hip circumferences (WC and HC), and waist-to-hip ratio (WHR). Analyses included 3,006 women from the French E3N prospective cohort study diagnosed with primary invasive breast cancer between 1995 and 2008. We investigated overall, breast cancer-specific, and disease-free survival, overall and according to stage, menopausal and hormonal status and year of diagnosis, using Cox proportional hazard models adjusted for tumor characteristics and lifestyle risk factors. Women with a prediagnostic HC > 100 cm were at increased risk of death from all causes (hazard ratio (HR)>100vs < 95 cm = 1.38, 95% Confidence Interval (CI) = 1.02-1.86, Ptrend = 0.02) and from breast cancer (HR>100vs < 95 cm = 1.50, CI = 1.03-2.17, Ptrend = 0.03), and of second invasive cancer event (HR>100vs < 95 cm = 1.36, CI = 1.11-1.67, Ptrend = 0.002), compared to those with HC <95 cm. Associations were stronger after adjustment for BMI. BMI, WC and WHR were not associated with survival after breast cancer. Our study underlines the importance of going beyond BMI when studying the association between adiposity and breast cancer survival. Further studies should be conducted to confirm our results on hip circumference.
KW - adiposity
KW - breast cancer survival
KW - disease-free survival
KW - mortality
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=84969921173&partnerID=8YFLogxK
U2 - 10.1002/ijc.30158
DO - 10.1002/ijc.30158
M3 - Article
C2 - 27106037
AN - SCOPUS:84969921173
SN - 0020-7136
VL - 139
SP - 1053
EP - 1064
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 5
ER -