TY - JOUR
T1 - Pre- and early postoperative GFAP serum levels in glioma and brain metastases
AU - Baumgarten, Peter
AU - Quick-Weller, Johanna
AU - Gessler, Florian
AU - Wagner, Marlies
AU - Tichy, Julia
AU - Forster, Marie Therese
AU - Foerch, Christian
AU - Seifert, Volker
AU - Mittelbronn, Michel
AU - Senft, Christian
N1 - Funding Information:
We thank Marina Heibel for excellent technical support. MM would like to thank the Luxembourg National Research Fond (FNR) for the support (FNR PEARL P16/BM/11192868 Grant). The authors declare that they have no conflict of interest.
Funding Information:
Acknowledgements We thank Marina Heibel for excellent technical support. MM would like to thank the Luxembourg National Research Fond (FNR) for the support (FNR PEARL P16/BM/11192868 Grant).
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Subject: To date there is no established tumor marker for the clinical follow-up of glioblastoma, WHO grade IV, (GBM) which constitutes the most frequent and malignant primary brain tumor. However, since there is promising data that the serum glial fibrillary acidic protein (sGFAP) may serve as a biomarker for glial brain tumors, this prospective study aimed at evaluating the diagnostic relevance of perioperative changes in sGFAP levels for the assessment of residual glial tumor tissue in patients undergoing surgery of intracerebral tumors. Methods: Serum GFAP was measured using an electrochemiluminometric immunoassay (ElecsysR GFAP prototype test, Roche Diagnostics, Penzberg/Germany) in 32 prospectively recruited patients between September 2009 and August 2010. Twenty-five were diagnosed with glioma and seven with brain metastases (BM). We assessed sGFAP levels prior to and at different time points during the early postoperative phase until patient discharge. Results: There were only significant differences in the pre-operative sGFAP levels of patients with gliomas compared to BM (0.18 vs. 0.08 µg/l; p = 0.0198, Welch’s t-Test). Even though there was an increase of sGFAP after surgery, there were no significant differences between glioma and BM patients at any other time point. Peak sGFAP levels where reached on postoperative day 1 followed by a slight decrease, but not reaching pre-operative levels until postop day 7. There was no significant correlation between postoperative glioma tumor volume and sGFAP levels in univariate analyses. Conclusion: According to our data sGFAP does not appear to be suitable to detect residual glioma tissue in the acute postoperative phase.
AB - Subject: To date there is no established tumor marker for the clinical follow-up of glioblastoma, WHO grade IV, (GBM) which constitutes the most frequent and malignant primary brain tumor. However, since there is promising data that the serum glial fibrillary acidic protein (sGFAP) may serve as a biomarker for glial brain tumors, this prospective study aimed at evaluating the diagnostic relevance of perioperative changes in sGFAP levels for the assessment of residual glial tumor tissue in patients undergoing surgery of intracerebral tumors. Methods: Serum GFAP was measured using an electrochemiluminometric immunoassay (ElecsysR GFAP prototype test, Roche Diagnostics, Penzberg/Germany) in 32 prospectively recruited patients between September 2009 and August 2010. Twenty-five were diagnosed with glioma and seven with brain metastases (BM). We assessed sGFAP levels prior to and at different time points during the early postoperative phase until patient discharge. Results: There were only significant differences in the pre-operative sGFAP levels of patients with gliomas compared to BM (0.18 vs. 0.08 µg/l; p = 0.0198, Welch’s t-Test). Even though there was an increase of sGFAP after surgery, there were no significant differences between glioma and BM patients at any other time point. Peak sGFAP levels where reached on postoperative day 1 followed by a slight decrease, but not reaching pre-operative levels until postop day 7. There was no significant correlation between postoperative glioma tumor volume and sGFAP levels in univariate analyses. Conclusion: According to our data sGFAP does not appear to be suitable to detect residual glioma tissue in the acute postoperative phase.
KW - Biomarker
KW - Brain metastasis
KW - GFAP
KW - Glioblastoma
KW - Resection
UR - http://www.scopus.com/inward/record.url?scp=85047352136&partnerID=8YFLogxK
U2 - 10.1007/s11060-018-2898-1
DO - 10.1007/s11060-018-2898-1
M3 - Article
C2 - 29797180
AN - SCOPUS:85047352136
SN - 0167-594X
VL - 139
SP - 541
EP - 546
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 3
ER -