Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Hans Erik Bøtker; Derek Hausenloy; Ioanna Andreadou; Salvatore Antonucci; Kerstin Boengler; Sean M. Davidson; Soni Deshwal; Yvan Devaux; Fabio Di Lisa; Moises Di Sante; Panagiotis Efentakis; Saveria Femminò; David García-Dorado; Zoltán Giricz; Borja Ibanez; Efstathios Iliodromitis; Nina Kaludercic; Petra Kleinbongard; Markus Neuhäuser; Michel Ovize; Pasquale Pagliaro; Michael Rahbek-Schmidt; Marisol Ruiz-Meana; Klaus Dieter Schlüter; Rainer Schulz; Andreas Skyschally; Catherine Wilder; Derek M. Yellon; Peter Ferdinandy; Gerd Heusch

doi:10.1007/s00395-018-0696-8

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Hans Erik Bøtker^*, Derek Hausenloy, Ioanna Andreadou, Salvatore Antonucci, Kerstin Boengler, Sean M. Davidson, Soni Deshwal, Yvan Devaux, Fabio Di Lisa, Moises Di Sante, Panagiotis Efentakis, Saveria Femminò, David García-Dorado, Zoltán Giricz, Borja Ibanez, Efstathios Iliodromitis, Nina Kaludercic, Petra Kleinbongard, Markus Neuhäuser, Michel OvizePasquale Pagliaro, Michael Rahbek-Schmidt, Marisol Ruiz-Meana, Klaus Dieter Schlüter, Rainer Schulz, Andreas Skyschally, Catherine Wilder, Derek M. Yellon, Peter Ferdinandy, Gerd Heusch

^*Corresponding author for this work

Cardiovascular Research Unit

Research output: Contribution to journal › Review article › peer-review

343 Citations (Scopus)

Original language	English
Article number	39
Journal	Basic Research in Cardiology
Volume	113
Issue number	5
DOIs	https://doi.org/10.1007/s00395-018-0696-8
Publication status	Published - 1 Sept 2018

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10.1007/s00395-018-0696-8

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Bøtker, H. E., Hausenloy, D., Andreadou, I., Antonucci, S., Boengler, K., Davidson, S. M., Deshwal, S., Devaux, Y., Di Lisa, F., Di Sante, M., Efentakis, P., Femminò, S., García-Dorado, D., Giricz, Z., Ibanez, B., Iliodromitis, E., Kaludercic, N., Kleinbongard, P., Neuhäuser, M., ... Heusch, G. (2018). Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Research in Cardiology, 113(5), Article 39. https://doi.org/10.1007/s00395-018-0696-8

@article{d84dbfaed8484aafbdd13596e84258e6,

title = "Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection",

author = "B{\o}tker, {Hans Erik} and Derek Hausenloy and Ioanna Andreadou and Salvatore Antonucci and Kerstin Boengler and Davidson, {Sean M.} and Soni Deshwal and Yvan Devaux and {Di Lisa}, Fabio and {Di Sante}, Moises and Panagiotis Efentakis and Saveria Femmin{\`o} and David Garc{\'i}a-Dorado and Zolt{\'a}n Giricz and Borja Ibanez and Efstathios Iliodromitis and Nina Kaludercic and Petra Kleinbongard and Markus Neuh{\"a}user and Michel Ovize and Pasquale Pagliaro and Michael Rahbek-Schmidt and Marisol Ruiz-Meana and Schl{\"u}ter, {Klaus Dieter} and Rainer Schulz and Andreas Skyschally and Catherine Wilder and Yellon, {Derek M.} and Peter Ferdinandy and Gerd Heusch",

note = "Funding Information: The present article was approved by the Management Committee of the EU-CARDIOPROTECTION COST Action CA16225: Ioanna Andreadou, Pavle Adamovski, Monika Bartekova, Christophe Beauloye, Luc Bertrand, David Biedermann, Vilmante Borutaite, Hans Erik B{\o}tker, Stefan Chlopicki, Maija Dambrova, Sean Davidson, Yvan Devaux, Fabio Di Lisa, Dragan Djuric, David Erlinge, In{\^e}s Falcao-Pires, P{\'e}ter Ferdinandy, Eleftheria Galatou, David Garc{\'i}a-Dorado, Alfonso T. Garcia-Sosa, Henrique Gir{\~a}o, Zoltan Giricz, Mariann Gyongyosi, Derek J Hausenloy, Donagh Healy, Gerd Heusch, Vladimir Jakovljevic, Jelena Jovanic, Frantisek Kolar, Brenda R Kwak, Przemyslaw Leszek, Edgars Liepins, Sarah Longnus, Jasna Marinovic, Danina Mirela Muntean, Lana Nezic, Michel Ovize, Pasquale Pagliaro, Clarissa Pedrosa da Costa Gomes, John Pernow, Andreas Persidis, S{\"o}ren Erik Pischke, Bruno K Podesser, Fabrice Prunier, Tanya Ravingerova, Marisol Ruiz-Meana, Rainer Schulz, Alina Scridon, Katrine Slagsvold, Jacob Thomsen L{\o}nborg, Belma Turan, Niels van Royen, Marko Vendelin, Stewart Walsh, Derek Yellon, Nace Zidar. An initiative of the European Union—CARDIOPROTECTION COST ACTION CA16225 “Realising the therapeutic potential of novel cardioprotective therapies” (www.cardioprotection.eu). Hans Erik B{\o}tker, Derek Hausenloy, Peter Ferdinandy and Gerd Heusch are joint first and last authors, as per COST ACTION policy. Professors Michael V. Cohen, MD, and James M. Downey, PhD, Dept. of Physiology, University of South Alabama, Mobile, Alabama, USA, served as guest editors for this article and were responsible for all editorial decisions, including selection of reviewers. Such transfer policy to guest editor(s) applies to all manuscripts with authors from the editor{\textquoteright}s institution. HEB and MRS are shareholders in CellAegis Inc. PF is founder and CEO of Pharmahungary, a Group of R&D companies. Funding Information: Funding HEB and MRS were supported by The Danish Council for Strategic Research (11‑108354), Novo Nordisk Foundation (Condi‑ tioning Based Intervention Strategies—ConBis) and Trygfonden. DH was supported by the British Heart Foundation (FS/10/039/28270), the National Institute for Health Research University College Lon‑ don Hospitals Biomedical Research Centre, Duke National University Singapore Medical School, Singapore Ministry of Health{\textquoteright}s National Medical Research Council and its Clinician Scientist‑Senior Investi‑ gator scheme (NMRC/CSA‑SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/GGAug16C006), and the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2016‑T2‑2‑021). PF is supported by grants from the Hungarian National Research, Develop‑ ment, and Innovation Office (OTKA K 109737, OTKA KH_17 125570, NVKP 16‑1‑2016‑0017, and VEKOP‑2.3.2‑16‑2016‑00002) and the Ministry of Human Capacities (Institutional Excellence Program for Higher Education). ZG is supported by the Bolyai Scholarship by the Hungarian Academy of Sciences. GH and PK were supported by the German Research Foundation (He 1320/18‑3 and SFB 1116 B8).",

year = "2018",

month = sep,

day = "1",

doi = "10.1007/s00395-018-0696-8",

language = "English",

volume = "113",

journal = "Basic Research in Cardiology",

issn = "0300-8428",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "5",

}

Bøtker, HE, Hausenloy, D, Andreadou, I, Antonucci, S, Boengler, K, Davidson, SM, Deshwal, S, Devaux, Y, Di Lisa, F, Di Sante, M, Efentakis, P, Femminò, S, García-Dorado, D, Giricz, Z, Ibanez, B, Iliodromitis, E, Kaludercic, N, Kleinbongard, P, Neuhäuser, M, Ovize, M, Pagliaro, P, Rahbek-Schmidt, M, Ruiz-Meana, M, Schlüter, KD, Schulz, R, Skyschally, A, Wilder, C, Yellon, DM, Ferdinandy, P & Heusch, G 2018, 'Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection', Basic Research in Cardiology, vol. 113, no. 5, 39. https://doi.org/10.1007/s00395-018-0696-8

TY - JOUR

T1 - Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

AU - Bøtker, Hans Erik

AU - Hausenloy, Derek

AU - Andreadou, Ioanna

AU - Antonucci, Salvatore

AU - Boengler, Kerstin

AU - Davidson, Sean M.

AU - Deshwal, Soni

AU - Devaux, Yvan

AU - Di Lisa, Fabio

AU - Di Sante, Moises

AU - Efentakis, Panagiotis

AU - Femminò, Saveria

AU - García-Dorado, David

AU - Giricz, Zoltán

AU - Ibanez, Borja

AU - Iliodromitis, Efstathios

AU - Kaludercic, Nina

AU - Kleinbongard, Petra

AU - Neuhäuser, Markus

AU - Ovize, Michel

AU - Pagliaro, Pasquale

AU - Rahbek-Schmidt, Michael

AU - Ruiz-Meana, Marisol

AU - Schlüter, Klaus Dieter

AU - Schulz, Rainer

AU - Skyschally, Andreas

AU - Wilder, Catherine

AU - Yellon, Derek M.

AU - Ferdinandy, Peter

AU - Heusch, Gerd

N1 - Funding Information: The present article was approved by the Management Committee of the EU-CARDIOPROTECTION COST Action CA16225: Ioanna Andreadou, Pavle Adamovski, Monika Bartekova, Christophe Beauloye, Luc Bertrand, David Biedermann, Vilmante Borutaite, Hans Erik Bøtker, Stefan Chlopicki, Maija Dambrova, Sean Davidson, Yvan Devaux, Fabio Di Lisa, Dragan Djuric, David Erlinge, Inês Falcao-Pires, Péter Ferdinandy, Eleftheria Galatou, David García-Dorado, Alfonso T. Garcia-Sosa, Henrique Girão, Zoltan Giricz, Mariann Gyongyosi, Derek J Hausenloy, Donagh Healy, Gerd Heusch, Vladimir Jakovljevic, Jelena Jovanic, Frantisek Kolar, Brenda R Kwak, Przemyslaw Leszek, Edgars Liepins, Sarah Longnus, Jasna Marinovic, Danina Mirela Muntean, Lana Nezic, Michel Ovize, Pasquale Pagliaro, Clarissa Pedrosa da Costa Gomes, John Pernow, Andreas Persidis, Sören Erik Pischke, Bruno K Podesser, Fabrice Prunier, Tanya Ravingerova, Marisol Ruiz-Meana, Rainer Schulz, Alina Scridon, Katrine Slagsvold, Jacob Thomsen Lønborg, Belma Turan, Niels van Royen, Marko Vendelin, Stewart Walsh, Derek Yellon, Nace Zidar. An initiative of the European Union—CARDIOPROTECTION COST ACTION CA16225 “Realising the therapeutic potential of novel cardioprotective therapies” (www.cardioprotection.eu). Hans Erik Bøtker, Derek Hausenloy, Peter Ferdinandy and Gerd Heusch are joint first and last authors, as per COST ACTION policy. Professors Michael V. Cohen, MD, and James M. Downey, PhD, Dept. of Physiology, University of South Alabama, Mobile, Alabama, USA, served as guest editors for this article and were responsible for all editorial decisions, including selection of reviewers. Such transfer policy to guest editor(s) applies to all manuscripts with authors from the editor’s institution. HEB and MRS are shareholders in CellAegis Inc. PF is founder and CEO of Pharmahungary, a Group of R&D companies. Funding Information: Funding HEB and MRS were supported by The Danish Council for Strategic Research (11‑108354), Novo Nordisk Foundation (Condi‑ tioning Based Intervention Strategies—ConBis) and Trygfonden. DH was supported by the British Heart Foundation (FS/10/039/28270), the National Institute for Health Research University College Lon‑ don Hospitals Biomedical Research Centre, Duke National University Singapore Medical School, Singapore Ministry of Health’s National Medical Research Council and its Clinician Scientist‑Senior Investi‑ gator scheme (NMRC/CSA‑SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/GGAug16C006), and the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2016‑T2‑2‑021). PF is supported by grants from the Hungarian National Research, Develop‑ ment, and Innovation Office (OTKA K 109737, OTKA KH_17 125570, NVKP 16‑1‑2016‑0017, and VEKOP‑2.3.2‑16‑2016‑00002) and the Ministry of Human Capacities (Institutional Excellence Program for Higher Education). ZG is supported by the Bolyai Scholarship by the Hungarian Academy of Sciences. GH and PK were supported by the German Research Foundation (He 1320/18‑3 and SFB 1116 B8).

PY - 2018/9/1

Y1 - 2018/9/1

UR - http://www.scopus.com/inward/record.url?scp=85051703838&partnerID=8YFLogxK

U2 - 10.1007/s00395-018-0696-8

DO - 10.1007/s00395-018-0696-8

M3 - Review article

C2 - 30120595

AN - SCOPUS:85051703838

SN - 0300-8428

VL - 113

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

IS - 5

M1 - 39

ER -

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

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