Approximately 10 to 15% of patients with breast cancer have a family history of breast and ovarian cancer. In about half of these patients a mutation in the genes of BRCA1 or 2 can be detected. A mutation in one of these genes entails a significant increase in the lifetime breast cancer risk, which can be up to 75%. These mutations have profound medical as well as psychological implications. In this paper I will discuss some of these implications and suggest a management scheme for these patients.
|Translated title of the contribution||Genetic predisposition for breast cancer|
|Number of pages||3|
|Publication status||Published - May 2003|
- Familial breast cancer