Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells

Keyphrases

• Cancer Cells 100%
• In Cancer 100%
• Protein Phosphatase 2A (PP2A) 100%
• Calmodulin 100%
• Phenothiazine 100%
• Fluphenazine 71%
• DT-061 57%
• Mustard 42%
• Calmodulin Antagonists 42%
• MDA-MB-231 28%
• High Potency 28%
• K-Ras 28%
• Apoptosis 14%
• Mitogen-activated Protein Kinase 14%
• Cell Proliferation 14%
• Cell Viability 14%
• Anticancer Agents 14%
• Inhibitory Activity 14%
• Anticancer Properties 14%
• Tumor Protein p53 (TP53) 14%
• Specific Inhibitor 14%
• BRAF V600E 14%
• C-Myc 14%
• In Vitro Activity 14%
• Cell Features 14%
• Functional Membrane 14%
• Spheroid Formation 14%
• 3D Spheroids 14%
• Repurposing 14%
• Dopamine Receptor 14%
• Neurotransmitter Receptors 14%
• Negligible Effects 14%
• Monoamine Neurotransmitters 14%
• Membrane Organization 14%
• KRAS G12C 14%
• Polypharmacology 14%
• Neurological Effects 14%
• G13D 14%
• MIA PaCa-2 Cells 14%
• Cancer Cell Stemness 14%
• Plasma Membrane Organization 14%
• H358 14%
• A375 14%
• G12C 14%
• Oncogenic Ras 14%
• AMG510 14%
• Cancer-associated 14%
• Antipsychotic Drugs 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Phenothiazine 100%
• Malignant Neoplasm 100%
• Phosphoprotein Phosphatase 2A 100%
• Calmodulin 100%
• Fluphenazine 71%
• Calmodulin Inhibitor 42%
• Tumor Suppressor Protein 14%
• Cell Viability 14%
• Repurposing 14%
• Cuniculidae 14%
• Monoamine 14%
• Anticarcinogen 14%
• Carcinogenesis 14%
• Dopamine Receptor 14%
• Neurotransmitter Receptor 14%
• Antipsychotic Drug 14%
• Side Effect 14%