TY - JOUR
T1 - Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice
AU - Bouayed, Jaouad
AU - Rammal, Hassan
AU - Younos, Chafique
AU - Soulimani, Rachid
N1 - Funding Information:
We are grateful to Pr. Didier Desor (Neurosciences, URAFPA, Université Henri Poincaré, Nancy) for helpful discussions and to Frédéric Desor for his technical assistance. We thank Research Department of BOIRON Laboratory for financial support.
PY - 2007/6/14
Y1 - 2007/6/14
N2 - Oxidative stress is involved in many acute and chronic diseases including cancer, cardiovascular disorders and neurodegenerative diseases. We studied the relationship between the level of intracellular reactive oxygen species in peripheral granulocytes and the estimated anxiety level of mice using the behavioral light/dark choice test. Our results indicate a linear and significant relationship between the intracellular redox status of peripheral blood granulocytes and different parameters of anxiety-related behavior including latency time (R2 = 0.737, P < 0.001), cumulative time spent in the lit box (R2 = 0.612, P < 0.01) and number of entries into the lit box (R2 = 0.661, P < 0.01). These results suggest a positive relationship between peripheral oxidative status and level of anxiety in mice.
AB - Oxidative stress is involved in many acute and chronic diseases including cancer, cardiovascular disorders and neurodegenerative diseases. We studied the relationship between the level of intracellular reactive oxygen species in peripheral granulocytes and the estimated anxiety level of mice using the behavioral light/dark choice test. Our results indicate a linear and significant relationship between the intracellular redox status of peripheral blood granulocytes and different parameters of anxiety-related behavior including latency time (R2 = 0.737, P < 0.001), cumulative time spent in the lit box (R2 = 0.612, P < 0.01) and number of entries into the lit box (R2 = 0.661, P < 0.01). These results suggest a positive relationship between peripheral oxidative status and level of anxiety in mice.
KW - Anxiety level
KW - Light/dark choice test
KW - Oxidative status
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=34250787612&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2007.02.055
DO - 10.1016/j.ejphar.2007.02.055
M3 - Article
C2 - 17395178
AN - SCOPUS:34250787612
SN - 0014-2999
VL - 564
SP - 146
EP - 149
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -