Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice

Jaouad Bouayed, Hassan Rammal, Chafique Younos, Rachid Soulimani*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

89 Citations (Scopus)

Abstract

Oxidative stress is involved in many acute and chronic diseases including cancer, cardiovascular disorders and neurodegenerative diseases. We studied the relationship between the level of intracellular reactive oxygen species in peripheral granulocytes and the estimated anxiety level of mice using the behavioral light/dark choice test. Our results indicate a linear and significant relationship between the intracellular redox status of peripheral blood granulocytes and different parameters of anxiety-related behavior including latency time (R2 = 0.737, P < 0.001), cumulative time spent in the lit box (R2 = 0.612, P < 0.01) and number of entries into the lit box (R2 = 0.661, P < 0.01). These results suggest a positive relationship between peripheral oxidative status and level of anxiety in mice.

Original languageEnglish
Pages (from-to)146-149
Number of pages4
JournalEuropean Journal of Pharmacology
Volume564
Issue number1-3
DOIs
Publication statusPublished - 14 Jun 2007
Externally publishedYes

Keywords

  • Anxiety level
  • Light/dark choice test
  • Oxidative status
  • Oxidative stress

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