Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease

Thorsten Schulte; Ludger Schöls; Thomas Müller; Dirk Woitalla; Klaus Berger; Rejko Krüger

doi:10.1016/S0304-3940(02)00301-4

Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease

Thorsten Schulte
, Ludger Schöls
, Thomas Müller
, Dirk Woitalla
, Klaus Berger
, Rejko Krüger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

95 Citations (Scopus)

Abstract

Several lines of evidence indicate that immune mechanisms are involved in the pathogenesis of neurodegenerative disorders. Activated immunocompetent cells and inflammatory cytokines are present in affected brain regions in patients with Alzheimer's (AD) and Parkinson's disease (PD). For AD biochemical and pathological data are supported by genetic studies identifying risk alleles for polymorphisms in regulatory regions of the interleukin-1 alpha (IL-1α-889) and interleukin-1 beta (IL-1β-511) gene, respectively. The partially overlapping pathology and inflammatory reaction pattern between AD and PD led us to investigate these polymorphisms in a large sample of 295 German PD patients and 270 healthy controls. We found T in position -511 in the IL-1β gene more frequent in patients compared to controls (χ²=4.44, P=0.034). For the IL-1α-889 polymorphism no significant difference between patients and controls was observed.

Original language	English
Pages (from-to)	70-72
Number of pages	3
Journal	Neuroscience Letters
Volume	326
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00301-4
Publication status	Published - 21 Jun 2002
Externally published	Yes

Keywords

Genetics
Inflammation
Interleukin-1 alpha
Interleukin-1 beta
Neurodegeneration
Parkinson's disease

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10.1016/S0304-3940(02)00301-4

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title = "Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease",

abstract = "Several lines of evidence indicate that immune mechanisms are involved in the pathogenesis of neurodegenerative disorders. Activated immunocompetent cells and inflammatory cytokines are present in affected brain regions in patients with Alzheimer's (AD) and Parkinson's disease (PD). For AD biochemical and pathological data are supported by genetic studies identifying risk alleles for polymorphisms in regulatory regions of the interleukin-1 alpha (IL-1α-889) and interleukin-1 beta (IL-1β-511) gene, respectively. The partially overlapping pathology and inflammatory reaction pattern between AD and PD led us to investigate these polymorphisms in a large sample of 295 German PD patients and 270 healthy controls. We found T in position -511 in the IL-1β gene more frequent in patients compared to controls (χ2=4.44, P=0.034). For the IL-1α-889 polymorphism no significant difference between patients and controls was observed.",

keywords = "Genetics, Inflammation, Interleukin-1 alpha, Interleukin-1 beta, Neurodegeneration, Parkinson's disease",

author = "Thorsten Schulte and Ludger Sch{\"o}ls and Thomas M{\"u}ller and Dirk Woitalla and Klaus Berger and Rejko Kr{\"u}ger",

note = "Funding Information: This study has been supported in part by a DFG grant Scho754/2-1 (to L.S. and R.K.).",

year = "2002",

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doi = "10.1016/S0304-3940(02)00301-4",

language = "English",

volume = "326",

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T1 - Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease

AU - Schulte, Thorsten

AU - Schöls, Ludger

AU - Müller, Thomas

AU - Woitalla, Dirk

AU - Berger, Klaus

AU - Krüger, Rejko

N1 - Funding Information: This study has been supported in part by a DFG grant Scho754/2-1 (to L.S. and R.K.).

PY - 2002/6/21

Y1 - 2002/6/21

N2 - Several lines of evidence indicate that immune mechanisms are involved in the pathogenesis of neurodegenerative disorders. Activated immunocompetent cells and inflammatory cytokines are present in affected brain regions in patients with Alzheimer's (AD) and Parkinson's disease (PD). For AD biochemical and pathological data are supported by genetic studies identifying risk alleles for polymorphisms in regulatory regions of the interleukin-1 alpha (IL-1α-889) and interleukin-1 beta (IL-1β-511) gene, respectively. The partially overlapping pathology and inflammatory reaction pattern between AD and PD led us to investigate these polymorphisms in a large sample of 295 German PD patients and 270 healthy controls. We found T in position -511 in the IL-1β gene more frequent in patients compared to controls (χ2=4.44, P=0.034). For the IL-1α-889 polymorphism no significant difference between patients and controls was observed.

AB - Several lines of evidence indicate that immune mechanisms are involved in the pathogenesis of neurodegenerative disorders. Activated immunocompetent cells and inflammatory cytokines are present in affected brain regions in patients with Alzheimer's (AD) and Parkinson's disease (PD). For AD biochemical and pathological data are supported by genetic studies identifying risk alleles for polymorphisms in regulatory regions of the interleukin-1 alpha (IL-1α-889) and interleukin-1 beta (IL-1β-511) gene, respectively. The partially overlapping pathology and inflammatory reaction pattern between AD and PD led us to investigate these polymorphisms in a large sample of 295 German PD patients and 270 healthy controls. We found T in position -511 in the IL-1β gene more frequent in patients compared to controls (χ2=4.44, P=0.034). For the IL-1α-889 polymorphism no significant difference between patients and controls was observed.

KW - Genetics

KW - Inflammation

KW - Interleukin-1 alpha

KW - Interleukin-1 beta

KW - Neurodegeneration

KW - Parkinson's disease

UR - https://www.scopus.com/pages/publications/0037150769

U2 - 10.1016/S0304-3940(02)00301-4

DO - 10.1016/S0304-3940(02)00301-4

M3 - Article

C2 - 12052541

AN - SCOPUS:0037150769

SN - 0304-3940

VL - 326

SP - 70

EP - 72

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease

Abstract

Keywords

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