Platinum(IV) N-heterocyclic carbene complexes: Their synthesis, characterisation and cytotoxic actIVity

M. Bouché, G. Dahm, M. Wantz, S. Fournel, T. Achard, S. Bellemin-Laponnaz*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

Platinum(ii) N-heterocyclic carbene complexes have been oxidized by bromine or iodobenzene dichloride to provide the fully characterised corresponding platinum(iv) NHC complexes. Antiproliferative activities of Pt(iv) NHC complexes were assayed against several cancer cell lines and the results were correlated with respect to their stability. Mechanistic investigations revealed that mitochondrial dysfunction and ROS production were associated with the cytotoxic process induced by these compounds.

Original languageEnglish
Pages (from-to)11362-11368
Number of pages7
JournalDalton Transactions
Volume45
Issue number28
DOIs
Publication statusPublished - 2016
Externally publishedYes

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