Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Marianne U. Jakobsen; Claus Dethlefsen; Karen M. Due; Nadia Slimani; Veronique Chajès; Anne M. May; Thorkild I.A. Sørensen; Jytte Halkjær; Anne Tjønneland; Francoise Clavel-Chapelon; Marie Christine Boutron-Ruault; Guy Fagherazzi; Birgit Teucher; Rudolf Kaaks; Heiner Boeing; Madlen Schütze; Antonia Trichopoulou; Dimosthenis Zylis; George Makrygiannis; Domenico Palli; Amalia Mattiello; Giovanna Tagliabue; Daphne L. Van Der A; H. B. Bueno-De-Mesquita; Laudina Rodríguez; Noémie Travier; Esther Molina-Montes; José M. Huerta; Aurelio Barricarte; Pilar Amiano; Jonas Manjer; Elisabet Wirfält; Ingegerd Johansson; Göran Hallmans; Kay Tee Khaw; Nicholas J. Wareham; Francesca Crowe; Isabelle Romieu; Elio Riboli; Petra H.M. Peeters; Kim Overvad

doi:10.1159/000330710

Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Marianne U. Jakobsen^*, Claus Dethlefsen, Karen M. Due, Nadia Slimani, Veronique Chajès, Anne M. May, Thorkild I.A. Sørensen, Jytte Halkjær, Anne Tjønneland, Francoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Guy Fagherazzi, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Madlen Schütze, Antonia Trichopoulou, Dimosthenis Zylis, George Makrygiannis, Domenico PalliAmalia Mattiello, Giovanna Tagliabue, Daphne L. Van Der A, H. B. Bueno-De-Mesquita, Laudina Rodríguez, Noémie Travier, Esther Molina-Montes, José M. Huerta, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfält, Ingegerd Johansson, Göran Hallmans, Kay Tee Khaw, Nicholas J. Wareham, Francesca Crowe, Isabelle Romieu, Elio Riboli, Petra H.M. Peeters, Kim Overvad

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

Original language	English
Pages (from-to)	312-318
Number of pages	7
Journal	Obesity Facts
Volume	4
Issue number	4
DOIs	https://doi.org/10.1159/000330710
Publication status	Published - Aug 2011
Externally published	Yes

Keywords

Body weight
Cohort study
Omega-3 fatty acids
Weight change
n-3 fatty acids

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10.1159/000330710

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Jakobsen, M. U., Dethlefsen, C., Due, K. M., Slimani, N., Chajès, V., May, A. M., Sørensen, T. I. A., Halkjær, J., Tjønneland, A., Clavel-Chapelon, F., Boutron-Ruault, M. C., Fagherazzi, G., Teucher, B., Kaaks, R., Boeing, H., Schütze, M., Trichopoulou, A., Zylis, D., Makrygiannis, G., ... Overvad, K. (2011). Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change. Obesity Facts, 4(4), 312-318. https://doi.org/10.1159/000330710

@article{7a2acd0a575545bbbbdf90d34d22ff4a,

title = "Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change",

abstract = "Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.",

keywords = "Body weight, Cohort study, Omega-3 fatty acids, Weight change, n-3 fatty acids",

author = "Jakobsen, {Marianne U.} and Claus Dethlefsen and Due, {Karen M.} and Nadia Slimani and Veronique Chaj{\`e}s and May, {Anne M.} and S{\o}rensen, {Thorkild I.A.} and Jytte Halkj{\ae}r and Anne Tj{\o}nneland and Francoise Clavel-Chapelon and Boutron-Ruault, {Marie Christine} and Guy Fagherazzi and Birgit Teucher and Rudolf Kaaks and Heiner Boeing and Madlen Sch{\"u}tze and Antonia Trichopoulou and Dimosthenis Zylis and George Makrygiannis and Domenico Palli and Amalia Mattiello and Giovanna Tagliabue and {Van Der A}, {Daphne L.} and Bueno-De-Mesquita, {H. B.} and Laudina Rodr{\'i}guez and No{\'e}mie Travier and Esther Molina-Montes and Huerta, {Jos{\'e} M.} and Aurelio Barricarte and Pilar Amiano and Jonas Manjer and Elisabet Wirf{\"a}lt and Ingegerd Johansson and G{\"o}ran Hallmans and Khaw, {Kay Tee} and Wareham, {Nicholas J.} and Francesca Crowe and Isabelle Romieu and Elio Riboli and Peeters, {Petra H.M.} and Kim Overvad",

note = "Funding Information: The research project was funded by Spar Nord Fonden, Det Obelske Familiefond, Jyske Bank as well as by Aalborg University, Denmark.",

year = "2011",

month = aug,

doi = "10.1159/000330710",

language = "English",

volume = "4",

pages = "312--318",

journal = "Obesity Facts",

issn = "1662-4025",

publisher = "S. Karger AG",

number = "4",

}

Jakobsen, MU, Dethlefsen, C, Due, KM, Slimani, N, Chajès, V, May, AM, Sørensen, TIA, Halkjær, J, Tjønneland, A, Clavel-Chapelon, F, Boutron-Ruault, MC, Fagherazzi, G, Teucher, B, Kaaks, R, Boeing, H, Schütze, M, Trichopoulou, A, Zylis, D, Makrygiannis, G, Palli, D, Mattiello, A, Tagliabue, G, Van Der A, DL, Bueno-De-Mesquita, HB, Rodríguez, L, Travier, N, Molina-Montes, E, Huerta, JM, Barricarte, A, Amiano, P, Manjer, J, Wirfält, E, Johansson, I, Hallmans, G, Khaw, KT, Wareham, NJ, Crowe, F, Romieu, I, Riboli, E, Peeters, PHM & Overvad, K 2011, 'Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change', Obesity Facts, vol. 4, no. 4, pp. 312-318. https://doi.org/10.1159/000330710

TY - JOUR

T1 - Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

AU - Jakobsen, Marianne U.

AU - Dethlefsen, Claus

AU - Due, Karen M.

AU - Slimani, Nadia

AU - Chajès, Veronique

AU - May, Anne M.

AU - Sørensen, Thorkild I.A.

AU - Halkjær, Jytte

AU - Tjønneland, Anne

AU - Clavel-Chapelon, Francoise

AU - Boutron-Ruault, Marie Christine

AU - Fagherazzi, Guy

AU - Teucher, Birgit

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Schütze, Madlen

AU - Trichopoulou, Antonia

AU - Zylis, Dimosthenis

AU - Makrygiannis, George

AU - Palli, Domenico

AU - Mattiello, Amalia

AU - Tagliabue, Giovanna

AU - Van Der A, Daphne L.

AU - Bueno-De-Mesquita, H. B.

AU - Rodríguez, Laudina

AU - Travier, Noémie

AU - Molina-Montes, Esther

AU - Huerta, José M.

AU - Barricarte, Aurelio

AU - Amiano, Pilar

AU - Manjer, Jonas

AU - Wirfält, Elisabet

AU - Johansson, Ingegerd

AU - Hallmans, Göran

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Crowe, Francesca

AU - Romieu, Isabelle

AU - Riboli, Elio

AU - Peeters, Petra H.M.

AU - Overvad, Kim

N1 - Funding Information: The research project was funded by Spar Nord Fonden, Det Obelske Familiefond, Jyske Bank as well as by Aalborg University, Denmark.

PY - 2011/8

Y1 - 2011/8

N2 - Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

AB - Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

KW - Body weight

KW - Cohort study

KW - Omega-3 fatty acids

KW - Weight change

KW - n-3 fatty acids

UR - http://www.scopus.com/inward/record.url?scp=80053027100&partnerID=8YFLogxK

U2 - 10.1159/000330710

DO - 10.1159/000330710

M3 - Article

C2 - 21921655

AN - SCOPUS:80053027100

SN - 1662-4025

VL - 4

SP - 312

EP - 318

JO - Obesity Facts

JF - Obesity Facts

IS - 4

ER -

Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

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Keywords

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