Plasma levels of insulin and amyloid β 42 are correlated in patients with amnestic mild cognitive impairment

Patrizio Odetti, Alessandra Piccini, Luca Giliberto, Roberta Borghi, Alessia Natale, Fiammetta Monacelli, Monica Marchese, Andrea Assini, Monica Colucci, Sergio Cammarata, Massimo Tabaton*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

Epidemiological and experimental data suggest that type 2 diabetes (DM2) and sporadic late-onset Alzheimer's disease (AD) share a common mechanism, that is able to produce accumulation of insulin and amyloid β 42 (Aβ42), the major pathogenic events respectively of the two conditions. In 71 non diabetic patients with amnestic mild cognitive impairment we found a significant linear correlation between fasting plasma levels of insulin and Aβ42 (R = +0.25, P < 0.05). The levels of both peptides were elevated in comparison to 48 age-matched cognitively normal controls. The correlation of insulin and Aβ42 plasma levels suggests a pathogenic link between DM2 and sporadic AD.

Original languageEnglish
Pages (from-to)243-245
Number of pages3
JournalJournal of Alzheimer's Disease
Volume8
Issue number3
DOIs
Publication statusPublished - 2005
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid β 42
  • Insulin
  • Mild cognitive impairment
  • Type 2 diabetes

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