Abstract
Epidemiological and experimental data suggest that type 2 diabetes (DM2) and sporadic late-onset Alzheimer's disease (AD) share a common mechanism, that is able to produce accumulation of insulin and amyloid β 42 (Aβ42), the major pathogenic events respectively of the two conditions. In 71 non diabetic patients with amnestic mild cognitive impairment we found a significant linear correlation between fasting plasma levels of insulin and Aβ42 (R = +0.25, P < 0.05). The levels of both peptides were elevated in comparison to 48 age-matched cognitively normal controls. The correlation of insulin and Aβ42 plasma levels suggests a pathogenic link between DM2 and sporadic AD.
Original language | English |
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Pages (from-to) | 243-245 |
Number of pages | 3 |
Journal | Journal of Alzheimer's Disease |
Volume | 8 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2005 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Amyloid β 42
- Insulin
- Mild cognitive impairment
- Type 2 diabetes