TY - JOUR
T1 - Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women
T2 - The EPIC-InterAct study
AU - Ekelund, U.
AU - Palla, L.
AU - Brage, S.
AU - Franks, P. W.
AU - Peters, T.
AU - Balkau, B.
AU - Diaz, M. J.T.
AU - Huerta, J. M.
AU - Agnoli, C.
AU - Arriola, L.
AU - Ardanaz, E.
AU - Boeing, H.
AU - Clavel-Chapelon, F.
AU - Crowe, F.
AU - Fagherazzi, G.
AU - Groop, L.
AU - Hainaut, P.
AU - Føns Johnsen, N.
AU - Kaaks, R.
AU - Khaw, K. T.
AU - Key, T. J.
AU - de Lauzon-Guillain, B.
AU - May, A.
AU - Monninkhof, E.
AU - Navarro, C.
AU - Nilsson, P.
AU - Nautrup Østergaard, J.
AU - Norat, T.
AU - Overvad, K.
AU - Palli, D.
AU - Panico, S.
AU - Redondo, M. L.
AU - Ricceri, F.
AU - Rolandsson, O.
AU - Romaguera, D.
AU - Romieu, I.
AU - Sánchez Pérez, M. J.
AU - Slimani, N.
AU - Spijkerman, A.
AU - Teucher, B.
AU - Tjonneland, A.
AU - Travier, N.
AU - Tumino, R.
AU - Vos, W.
AU - Vigl, M.
AU - Sharp, S.
AU - Langenberg, C.
AU - Forouhi, N.
AU - Riboli, E.
AU - Feskens, E.
AU - The InterAct Consortium
N1 - Funding Information:
Funding This study was supported by funding from the European Union (Integrated Project LSHM-CT-2006-037197 in the Framework Programme 6 of the European Community) and the Medical Research Council, UK.
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Aims/hypothesis: We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. Methods: The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. Results: A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Conclusions/interpretation: Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women.
AB - Aims/hypothesis: We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. Methods: The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. Results: A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Conclusions/interpretation: Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women.
KW - Abdominal obesity
KW - Case-cohort study
KW - Incident diabetes
KW - Obesity
KW - Physical activity
UR - http://www.scopus.com/inward/record.url?scp=84866420586&partnerID=8YFLogxK
U2 - 10.1007/s00125-012-2532-2
DO - 10.1007/s00125-012-2532-2
M3 - Article
C2 - 22526603
AN - SCOPUS:84866420586
SN - 0012-186X
VL - 55
SP - 1944
EP - 1952
JO - Diabetologia
JF - Diabetologia
IS - 7
ER -