Pherokine-2 and -3: Two Drosophila molecules related to pheromone/odor-binding proteins induced by viral and bacterial infections

Laurence Sabatier, Emmanuelle Jouanguy, Catherine Dostert, Daniel Zachary, Jean Luc Dimarcq, Philippe Bulet, Jean Luc Imler*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)

Abstract

Drosophila is a powerful model system to study the regulatory and effector mechanisms of innate immunity. To identify molecules induced in the course of viral infection in this insect, we have developed a model based on intrathoracic injection of the picorna-like Drosophila C virus (DCV). We have used MALDI-TOF mass spectrometry to compare the hemolymph of DCV infected flies and control flies. By contrast with the strong humoral response triggered by injection of bacteria or fungal spores, we have identified only one molecule induced in the hemolymph of virus infected flies. This molecule, pherokine-2 (Phk-2), is related to OS-D/A10 (Phk-1), which was previously characterized as a putative odor/pheromone binding protein specifically expressed in antennae. The virus-induced molecule is also similar to the product of the gene CG9358 (Phk-3), which is induced by septic injury. Both Phk-2 and Phk-3 are strongly expressed during metamorphosis, suggesting that they may participate in tissue-remodeling.

Original languageEnglish
Pages (from-to)3398-3407
Number of pages10
JournalEuropean Journal of Biochemistry
Volume270
Issue number16
DOIs
Publication statusPublished - Aug 2003
Externally publishedYes

Keywords

  • Antiviral
  • Drosophila C virus
  • Host-defense
  • Odor-binding protein
  • Tissue remodelling

Fingerprint

Dive into the research topics of 'Pherokine-2 and -3: Two Drosophila molecules related to pheromone/odor-binding proteins induced by viral and bacterial infections'. Together they form a unique fingerprint.

Cite this