TY - JOUR
T1 - Pertussis in Lao PDR
T2 - Seroprevalence and disease
AU - Kleine, Daria
AU - Billamay, Somxay
AU - Chanthavilay, Phetsavanh
AU - Mongkhoune, Sodaly
AU - Keokhamphoui, Chirapha
AU - Souksakhone, Chanthala
AU - Nouanthong, Phonethipsavanh
AU - Khamphaphongphane, Bouaphan
AU - Muller, Claude P.
AU - Black, Antony P.
N1 - Funding Information:
This work was supported by the Ministry of Foreign and European Affairs, Luxembourg (project ?Lao Luxembourg Partnership for Research and Capacity Building in Infectious Disease Surveillance II?, PARECIDS II).
Funding Information:
This work was supported by the Ministry of Foreign and European Affairs, Luxembourg (project “Lao Luxembourg Partnership for Research and Capacity Building in Infectious Disease Surveillance II”, PARECIDS II).
Publisher Copyright:
© 2020 The Author(s)
PY - 2020/6
Y1 - 2020/6
N2 - Objectives: Pertussis is a debilitating vaccine-preventable infection. The aim of this study was to determine susceptibility and exposure to pertussis in Lao PDR in different age groups and subpopulations. Methods: A total 3072 serum samples were obtained from different cohorts: children with documented vaccination, pre-schoolers, schoolchildren, blood donors, healthcare workers (HCWs), and pregnant women and paired cord blood. Samples were tested for anti-pertussis toxin IgG antibodies. A history of Bordetella pertussis exposure was defined according to antibody titres. Four hundred and seventy-five throat swabs and nasopharyngeal aspirates were analysed by PCR for the presence of B. pertussis in symptomatic children at the Children's Hospital in Vientiane. Results: Overall pertussis seroprevalence was 57.5%. The prevalence of titres indicating acute infection or recent vaccination or infection/vaccination within the last 12 months ranged from 7.4% (100/1356) in adults to 21.4% (25/117) in pre-schoolers (age 1–5 years). B. pertussis was detected in 1.05% (5/475) of children with respiratory symptoms in Vientiane Capital. Conclusions: It is suggested that routine childhood vaccination, in particular outreach, as well as vaccination of HCWs should be strengthened. A childhood booster and vaccination of pregnant mothers should be considered. There is also a need to improve reporting and to introduce pertussis testing in at least one central facility.
AB - Objectives: Pertussis is a debilitating vaccine-preventable infection. The aim of this study was to determine susceptibility and exposure to pertussis in Lao PDR in different age groups and subpopulations. Methods: A total 3072 serum samples were obtained from different cohorts: children with documented vaccination, pre-schoolers, schoolchildren, blood donors, healthcare workers (HCWs), and pregnant women and paired cord blood. Samples were tested for anti-pertussis toxin IgG antibodies. A history of Bordetella pertussis exposure was defined according to antibody titres. Four hundred and seventy-five throat swabs and nasopharyngeal aspirates were analysed by PCR for the presence of B. pertussis in symptomatic children at the Children's Hospital in Vientiane. Results: Overall pertussis seroprevalence was 57.5%. The prevalence of titres indicating acute infection or recent vaccination or infection/vaccination within the last 12 months ranged from 7.4% (100/1356) in adults to 21.4% (25/117) in pre-schoolers (age 1–5 years). B. pertussis was detected in 1.05% (5/475) of children with respiratory symptoms in Vientiane Capital. Conclusions: It is suggested that routine childhood vaccination, in particular outreach, as well as vaccination of HCWs should be strengthened. A childhood booster and vaccination of pregnant mothers should be considered. There is also a need to improve reporting and to introduce pertussis testing in at least one central facility.
KW - Bordetella pertussis
KW - Lao PDR
KW - Seroprevalence
KW - Vaccine immunogenicity
KW - Vaccine-preventable infection
UR - http://www.scopus.com/inward/record.url?scp=85084237671&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2020.03.074
DO - 10.1016/j.ijid.2020.03.074
M3 - Article
C2 - 32278108
AN - SCOPUS:85084237671
SN - 1201-9712
VL - 95
SP - 282
EP - 287
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -