TY - JOUR
T1 - Pediatric Oncology Clinical Trials and Collaborative Research in Africa
T2 - Current Landscape and Future Perspectives
AU - van Heerden, Jaques
AU - Zaghloul, Mohamed
AU - Neven, Anouk
AU - de Rojas, Teresa
AU - Geel, Jennifer
AU - Patte, Catherine
AU - Balagadde-Kambugu, Joyce
AU - Hesseling, Peter
AU - Tchintseme, Francine
AU - Bouffet, Eric
AU - Hessissen, Laila
AU - Challinor, Julia
AU - SIOP Africa
N1 - Funding Information:
Support for T.d.R.?s research activities by a grant from Fundaci?n Juegaterapia, Madrid, Spain.
Funding Information:
African-based oncology fellowship programs French collaborations Global HOPE and North American–based collaborations South African and African Fellowship Program collaborations European-based collaborations, including the Netherlands, Belgium, and the United Kingdom
Publisher Copyright:
Copyright © 2020 American Society of Clinical Oncology.
PY - 2020
Y1 - 2020
N2 - PURPOSE Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opportunities for research collaborations. METHODS The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials.gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. RESULTS The SIOP global mapping survey received responses from 47 of 54 African countries, of which 23 have active clinical research programs. A preliminary search of ClinicalTrials.gov showed that only 105 (12.1%) of 868 African oncology studies included children and adolescents. Of these, 53 (50.5%) were interventional trials according to the registry’s classification. The small number of African trials for children and adolescents included palliative care and leukemia trials. In African oncology journals and international pediatric oncology journals,, 1% of the pediatric oncology publications come from Africa. Services and research were strengthened by international collaboration. National studies focused on clinical needs, local challenges, or interventional priorities. Both the literature review and the expert opinions highlight the need to expand clinical research in Africa, despite ongoing regional instability and lack of resources. CONCLUSION While a low number of pediatric clinical treatment trials are open to African children and adolescents, clinical research of high quality is being done in Africa. Several initiatives are stimulating the development of the research capacity across the continent, which should increase the publication output.
AB - PURPOSE Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opportunities for research collaborations. METHODS The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials.gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. RESULTS The SIOP global mapping survey received responses from 47 of 54 African countries, of which 23 have active clinical research programs. A preliminary search of ClinicalTrials.gov showed that only 105 (12.1%) of 868 African oncology studies included children and adolescents. Of these, 53 (50.5%) were interventional trials according to the registry’s classification. The small number of African trials for children and adolescents included palliative care and leukemia trials. In African oncology journals and international pediatric oncology journals,, 1% of the pediatric oncology publications come from Africa. Services and research were strengthened by international collaboration. National studies focused on clinical needs, local challenges, or interventional priorities. Both the literature review and the expert opinions highlight the need to expand clinical research in Africa, despite ongoing regional instability and lack of resources. CONCLUSION While a low number of pediatric clinical treatment trials are open to African children and adolescents, clinical research of high quality is being done in Africa. Several initiatives are stimulating the development of the research capacity across the continent, which should increase the publication output.
UR - http://www.scopus.com/inward/record.url?scp=85089301355&partnerID=8YFLogxK
U2 - 10.1200/GO.20.00159
DO - 10.1200/GO.20.00159
M3 - Review article
C2 - 32762563
AN - SCOPUS:85089301355
SN - 2378-9506
SP - 1264
EP - 1275
JO - JCO Global Oncology
JF - JCO Global Oncology
IS - 6
ER -