Parvovirus-based combinatorial immunotherapy: A reinforced therapeutic strategy against poor-prognosis solid cancers

Assia Angelova*, Tiago Ferreira, Clemens Bretscher, Jean Rommelaere, Antonio Marchini

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    9 Citations (Scopus)

    Abstract

    Resistance to anticancer treatments poses continuing challenges to oncology researchers and clinicians. The underlying mechanisms are complex and multifactorial. However, the immunologically cold tumor microenvironment (TME) has recently emerged as one of the critical players in cancer progression and therapeutic resistance. Therefore, TME modulation through induction of an immunological switch towards inflammation (warming up) is among the leading approaches in modern oncology. Oncolytic viruses (OVs) are seen today not merely as tumor cell-killing (oncolytic) agents, but also as cancer therapeutics with multimodal antitumor action. Due to their intrinsic or engineered capacity for overcoming immune escape mechanisms, warming up the TME and promoting antitumor immune responses, OVs hold the potential for creating a proinflammatory background, which may in turn facilitate the action of other (immunomodulating) drugs. The latter provides the basis for the development of OV-based immunostimulatory anticancer combinations. This review deals with the smallest among all OVs, the H-1 parvovirus (H-1PV), and focuses on H-1PV-based combinatorial approaches, whose efficiency has been proven in preclinical and/or clinical settings. Special focus is given to cancer types with the most devastating impact on life expectancy that urgently call for novel therapies.

    Original languageEnglish
    Article number342
    Pages (from-to)1-15
    Number of pages15
    JournalCancers
    Volume13
    Issue number2
    DOIs
    Publication statusPublished - 19 Jan 2021

    Keywords

    • Colorectal cancer
    • Combination therapy
    • Glioblastoma
    • Immunotherapy
    • Melanoma
    • Oncolytic
    • Pancreatic cancer
    • Parvovirus
    • Tumor microenvironment

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