Parent-led massage and sleep EEG for term-born infants: A randomized controlled parallel-group study

Soraia Ventura; Sean R Mathieson; Marc P O'Sullivan; John M O'Toole; Vicki Livingstone; Ronit M Pressler; Eugene M Dempsey; Deirdre M Murray; Geraldine B Boylan

doi:10.1111/dmcn.15565

Parent-led massage and sleep EEG for term-born infants: A randomized controlled parallel-group study

Soraia Ventura, Sean R Mathieson, Marc P O'Sullivan, John M O'Toole, Vicki Livingstone, Ronit M Pressler, Eugene M Dempsey, Deirdre M Murray, Geraldine B Boylan^*

^*Corresponding author for this work

Clinical Research Project Management 2

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

AIM: To examine the impact of parent-led massage on the sleep electroencephalogram (EEG) features of typically developing term-born infants at 4 months.

METHOD: Infants recruited at birth were randomized to intervention (routine parent-led massage) and control groups. Infants had a daytime sleep EEG at 4 months and were assessed using the Griffiths Scales of Child Development, Third Edition at 4 and 18 months. Comparative analysis between groups and subgroup analysis between regularly massaged and never-massaged infants were performed. Groups were compared for sleep stage, sleep spindles, quantitative EEG (primary analysis), and Griffiths using the Mann-Whitney U test.

RESULTS: In total, 179 out of 182 infants (intervention: 83 out of 84; control: 96 out of 98) had a normal sleep EEG. Median (interquartile range) sleep duration was 49.8 minutes (39.1-71.4) (n = 156). A complete first sleep cycle was seen in 67 out of 83 (81%) and 72 out of 96 (75%) in the intervention and control groups respectively. Groups did not differ in sleep stage durations, latencies to sleep and to rapid eye movement sleep. Sleep spindle spectral power was greater in the intervention group in main and subgroup analyses. The intervention group showed greater EEG magnitudes, and lower interhemispherical coherence on subgroup analyses. Griffiths assessments at 4 months (n = 179) and 18 months (n = 173) showed no group differences in the main and subgroup analyses.

INTERPRETATION: Routine massage is associated with distinct functional brain changes at 4 months.

Original language	English
Pages (from-to)	1395-1407
Number of pages	13
Journal	Developmental Medicine and Child Neurology
Volume	65
Issue number	10
Early online date	14 Mar 2023
DOIs	https://doi.org/10.1111/dmcn.15565
Publication status	Published - Oct 2023

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@article{fa7415fd2cba4b00bd99a37d10199c87,

title = "Parent-led massage and sleep EEG for term-born infants: A randomized controlled parallel-group study",

abstract = "AIM: To examine the impact of parent-led massage on the sleep electroencephalogram (EEG) features of typically developing term-born infants at 4 months.METHOD: Infants recruited at birth were randomized to intervention (routine parent-led massage) and control groups. Infants had a daytime sleep EEG at 4 months and were assessed using the Griffiths Scales of Child Development, Third Edition at 4 and 18 months. Comparative analysis between groups and subgroup analysis between regularly massaged and never-massaged infants were performed. Groups were compared for sleep stage, sleep spindles, quantitative EEG (primary analysis), and Griffiths using the Mann-Whitney U test.RESULTS: In total, 179 out of 182 infants (intervention: 83 out of 84; control: 96 out of 98) had a normal sleep EEG. Median (interquartile range) sleep duration was 49.8 minutes (39.1-71.4) (n = 156). A complete first sleep cycle was seen in 67 out of 83 (81%) and 72 out of 96 (75%) in the intervention and control groups respectively. Groups did not differ in sleep stage durations, latencies to sleep and to rapid eye movement sleep. Sleep spindle spectral power was greater in the intervention group in main and subgroup analyses. The intervention group showed greater EEG magnitudes, and lower interhemispherical coherence on subgroup analyses. Griffiths assessments at 4 months (n = 179) and 18 months (n = 173) showed no group differences in the main and subgroup analyses.INTERPRETATION: Routine massage is associated with distinct functional brain changes at 4 months.",

author = "Soraia Ventura and Mathieson, {Sean R} and O'Sullivan, {Marc P} and O'Toole, {John M} and Vicki Livingstone and Pressler, {Ronit M} and Dempsey, {Eugene M} and Murray, {Deirdre M} and Boylan, {Geraldine B}",

note = " FUNDING INFORMATION Science Foundation Ireland grants 12/RC/2272 and 15/SP/3091, and Johnson & Johnson. JMOT is funded by Science Foundation Ireland (15/SIRG/3580). RMP is an investigator with UCB and does consultancy work for Kephala Ltd, Ireland; she served as a speaker and/or on advisory boards for Natus, GW Pharmaceuticals, and Union Chimique Belge (UCB). RMP's research is supported by the National Institute of Health Research (NIHR) Biomedical Research Centre at Great Ormond Street Hospital, Cambridge Biomedical Research Centre, the NIHR, and the Evelyn Trust. GBB has a consultancy with UCB and Nihon Kohden; she is co-founder of Kephala Ltd and CergenX Ltd {\textcopyright} 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.",

year = "2023",

month = oct,

doi = "10.1111/dmcn.15565",

language = "English",

volume = "65",

pages = "1395--1407",

journal = "Developmental Medicine and Child Neurology",

issn = "0012-1622",

publisher = "Wiley-Blackwell",

number = "10",

}

TY - JOUR

T1 - Parent-led massage and sleep EEG for term-born infants

T2 - A randomized controlled parallel-group study

AU - Ventura, Soraia

AU - Mathieson, Sean R

AU - O'Sullivan, Marc P

AU - O'Toole, John M

AU - Livingstone, Vicki

AU - Pressler, Ronit M

AU - Dempsey, Eugene M

AU - Murray, Deirdre M

AU - Boylan, Geraldine B

N1 - FUNDING INFORMATION Science Foundation Ireland grants 12/RC/2272 and 15/SP/3091, and Johnson & Johnson. JMOT is funded by Science Foundation Ireland (15/SIRG/3580). RMP is an investigator with UCB and does consultancy work for Kephala Ltd, Ireland; she served as a speaker and/or on advisory boards for Natus, GW Pharmaceuticals, and Union Chimique Belge (UCB). RMP's research is supported by the National Institute of Health Research (NIHR) Biomedical Research Centre at Great Ormond Street Hospital, Cambridge Biomedical Research Centre, the NIHR, and the Evelyn Trust. GBB has a consultancy with UCB and Nihon Kohden; she is co-founder of Kephala Ltd and CergenX Ltd © 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.

PY - 2023/10

Y1 - 2023/10

N2 - AIM: To examine the impact of parent-led massage on the sleep electroencephalogram (EEG) features of typically developing term-born infants at 4 months.METHOD: Infants recruited at birth were randomized to intervention (routine parent-led massage) and control groups. Infants had a daytime sleep EEG at 4 months and were assessed using the Griffiths Scales of Child Development, Third Edition at 4 and 18 months. Comparative analysis between groups and subgroup analysis between regularly massaged and never-massaged infants were performed. Groups were compared for sleep stage, sleep spindles, quantitative EEG (primary analysis), and Griffiths using the Mann-Whitney U test.RESULTS: In total, 179 out of 182 infants (intervention: 83 out of 84; control: 96 out of 98) had a normal sleep EEG. Median (interquartile range) sleep duration was 49.8 minutes (39.1-71.4) (n = 156). A complete first sleep cycle was seen in 67 out of 83 (81%) and 72 out of 96 (75%) in the intervention and control groups respectively. Groups did not differ in sleep stage durations, latencies to sleep and to rapid eye movement sleep. Sleep spindle spectral power was greater in the intervention group in main and subgroup analyses. The intervention group showed greater EEG magnitudes, and lower interhemispherical coherence on subgroup analyses. Griffiths assessments at 4 months (n = 179) and 18 months (n = 173) showed no group differences in the main and subgroup analyses.INTERPRETATION: Routine massage is associated with distinct functional brain changes at 4 months.

AB - AIM: To examine the impact of parent-led massage on the sleep electroencephalogram (EEG) features of typically developing term-born infants at 4 months.METHOD: Infants recruited at birth were randomized to intervention (routine parent-led massage) and control groups. Infants had a daytime sleep EEG at 4 months and were assessed using the Griffiths Scales of Child Development, Third Edition at 4 and 18 months. Comparative analysis between groups and subgroup analysis between regularly massaged and never-massaged infants were performed. Groups were compared for sleep stage, sleep spindles, quantitative EEG (primary analysis), and Griffiths using the Mann-Whitney U test.RESULTS: In total, 179 out of 182 infants (intervention: 83 out of 84; control: 96 out of 98) had a normal sleep EEG. Median (interquartile range) sleep duration was 49.8 minutes (39.1-71.4) (n = 156). A complete first sleep cycle was seen in 67 out of 83 (81%) and 72 out of 96 (75%) in the intervention and control groups respectively. Groups did not differ in sleep stage durations, latencies to sleep and to rapid eye movement sleep. Sleep spindle spectral power was greater in the intervention group in main and subgroup analyses. The intervention group showed greater EEG magnitudes, and lower interhemispherical coherence on subgroup analyses. Griffiths assessments at 4 months (n = 179) and 18 months (n = 173) showed no group differences in the main and subgroup analyses.INTERPRETATION: Routine massage is associated with distinct functional brain changes at 4 months.

UR - https://pubmed.ncbi.nlm.nih.gov/36917624

U2 - 10.1111/dmcn.15565

DO - 10.1111/dmcn.15565

M3 - Article

C2 - 36917624

SN - 0012-1622

VL - 65

SP - 1395

EP - 1407

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

IS - 10

ER -

Parent-led massage and sleep EEG for term-born infants: A randomized controlled parallel-group study

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