Oximoaspergillimide, a fungal derivative from a marine isolate of Aspergillus sp.

Faviola Cardoso-Martínez; José M. De La Rosa; Ana R. Díaz-Marrero; José Darias; Luis D'Croz; Claudia Cerella; Marc Diederich; Mercedes Cueto

doi:10.1002/ejoc.201403668

Oximoaspergillimide, a fungal derivative from a marine isolate of Aspergillus sp.

Faviola Cardoso-Martínez
, José M. De La Rosa
, Ana R. Díaz-Marrero
, José Darias
, Luis D'Croz
, Claudia Cerella
, Marc Diederich
, Mercedes Cueto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

A new alkaloid, oximoaspergillimide (1), and the known neohydroxyaspergillic (2) and neoaspergillic (3) acids, have been isolated from the extract of a cultured marine-derived fungus (strain CF07002) identified as a member of the genus Aspergillus. The structure of 1 was determined by interpretation of NMR spectroscopic data, and confirmed by synthesis. The antimicrobial and cytotoxic activities of compounds 1-3 were evaluated.

Original language	English
Pages (from-to)	2256-2261
Number of pages	6
Journal	European Journal of Organic Chemistry
Volume	2015
Issue number	10
DOIs	https://doi.org/10.1002/ejoc.201403668
Publication status	Published - Apr 2015
Externally published	Yes

Keywords

Alkaloids
Antimicrobial activity
Cytotoxicity
Natural products
Oximes
Structure elucidation

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10.1002/ejoc.201403668

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title = "Oximoaspergillimide, a fungal derivative from a marine isolate of Aspergillus sp.",

abstract = "A new alkaloid, oximoaspergillimide (1), and the known neohydroxyaspergillic (2) and neoaspergillic (3) acids, have been isolated from the extract of a cultured marine-derived fungus (strain CF07002) identified as a member of the genus Aspergillus. The structure of 1 was determined by interpretation of NMR spectroscopic data, and confirmed by synthesis. The antimicrobial and cytotoxic activities of compounds 1-3 were evaluated.",

keywords = "Alkaloids, Antimicrobial activity, Cytotoxicity, Natural products, Oximes, Structure elucidation",

author = "Faviola Cardoso-Mart{\'i}nez and \{De La Rosa\}, \{Jos{\'e} M.\} and D{\'i}az-Marrero, \{Ana R.\} and Jos{\'e} Darias and Luis D'Croz and Claudia Cerella and Marc Diederich and Mercedes Cueto",

note = "Publisher Copyright: Copyright {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

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doi = "10.1002/ejoc.201403668",

language = "English",

volume = "2015",

pages = "2256--2261",

journal = "European Journal of Organic Chemistry",

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publisher = "Wiley-VCH Verlag",

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AU - Cardoso-Martínez, Faviola

AU - De La Rosa, José M.

AU - Díaz-Marrero, Ana R.

AU - Darias, José

AU - D'Croz, Luis

AU - Cerella, Claudia

AU - Diederich, Marc

AU - Cueto, Mercedes

PY - 2015/4

Y1 - 2015/4

N2 - A new alkaloid, oximoaspergillimide (1), and the known neohydroxyaspergillic (2) and neoaspergillic (3) acids, have been isolated from the extract of a cultured marine-derived fungus (strain CF07002) identified as a member of the genus Aspergillus. The structure of 1 was determined by interpretation of NMR spectroscopic data, and confirmed by synthesis. The antimicrobial and cytotoxic activities of compounds 1-3 were evaluated.

AB - A new alkaloid, oximoaspergillimide (1), and the known neohydroxyaspergillic (2) and neoaspergillic (3) acids, have been isolated from the extract of a cultured marine-derived fungus (strain CF07002) identified as a member of the genus Aspergillus. The structure of 1 was determined by interpretation of NMR spectroscopic data, and confirmed by synthesis. The antimicrobial and cytotoxic activities of compounds 1-3 were evaluated.

KW - Alkaloids

KW - Antimicrobial activity

KW - Cytotoxicity

KW - Natural products

KW - Oximes

KW - Structure elucidation

UR - https://www.scopus.com/pages/publications/84925656729

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DO - 10.1002/ejoc.201403668

M3 - Article

AN - SCOPUS:84925656729

SN - 1434-193X

VL - 2015

SP - 2256

EP - 2261

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 10

ER -

Oximoaspergillimide, a fungal derivative from a marine isolate of Aspergillus sp.

Abstract

Keywords

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