Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet

Marie Eve Dumez, Julie Herman, Vincenzo Campizi, Moreno Galleni, Alain Jacquet, Andy Chevigné*

*Corresponding author for this work

    Research output: Contribution to journalShort surveypeer-review

    27 Citations (Scopus)

    Abstract

    In more than 20% of the world population, sensitization to house dust mite allergens triggers typical allergic diseases such as allergic rhinitis and asthma. Amongst the 23 mite allergen groups hitherto identified, group 1 is cysteine proteases belonging to the papain-like family whereas groups 3, 6, and 9 are serine proteases displaying trypsin, chymotrypsin, and collagenolytic activities, respectively. While these proteases are more likely to be involved in the mite digestive system, they also play critical roles in the initiation and in the chronicity of the allergic response notably through the activation of innate immune pathways. All these allergenic proteases are expressed in mite as inactive precursor form. Until recently, the exact mechanisms of their maturation into active proteases remained to be fully elucidated. Recent breakthroughs in the understanding of the activation mechanisms of mite allergenic protease precursors have highlighted an uncommon and unique maturation pathway orchestrated by group 1 proteases that tightly regulates the proteolytic activities of groups 1, 3, 6, and 9 through complex intra- or inter-molecular mechanisms. This review presents and discusses the currently available knowledge of the activation mechanisms of group 1, 3, 6, and 9 allergens of Dermatophagoides pteronyssinus laying special emphasis on their localization, regulation, and interconnection.

    Original languageEnglish
    Article numberArticle 138
    JournalFrontiers in Immunology
    Volume5
    Issue numberMAR
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Activation cascade
    • Allergen
    • Der p 1
    • Interaction
    • Localization
    • Mite
    • Proteases

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