Nuclear structure and intranuclear retention of premature RNAs

Olivier Gadal*, Ulf Nehrbass

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


Eukaryotic cells are highly compartmentalized, each compartment being surrounded by a lipid bilayer. This membrane-based organization allows cells to use their volumes to encode information. The lack of intranuclear membranes suggested that the nucleus was largely devoid of structural organization. However, recent work has defined numerous specialized nuclear subdomains. Importantly, RNA processing factors do not display random distribution but cluster in defined nuclear bodies. Although these structures are well characterized morphologically, their function in relation to RNA metabolism remains elusive. In this review, we will discuss the putative participation of nuclear substructures in a quality control step of RNA biogenesis, the nuclear retention of premature RNA.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalJournal of Structural Biology
Issue number1-3
Publication statusPublished - 2002
Externally publishedYes


  • Nuclear retention
  • Nuclear structure
  • Pre-mRNA


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