Noncoding RNAs in age-related cardiovascular diseases

Amela Jusic, Pınar Buket Thomas, Stephanie Bezzina Wettinger, Soner Doğan, Rosienne Farrugia, Carlo Gaetano, Bilge Güvenç Tuna, Florence Pinet, Emma L. Robinson, Simon Tual-Chalot, Konstantinos Stellos, Yvan Devaux*, on behalf of EU-CardioRNA COST Action CA17129

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
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Abstract

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.

Original languageEnglish
Article number101610
JournalAgeing Research Reviews
Volume77
DOIs
Publication statusPublished - May 2022

Keywords

  • Ageing
  • Cardiovascular disease
  • Inflammageing
  • Noncoding RNAs

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