TY - JOUR
T1 - Noncoding RNAs in age-related cardiovascular diseases
AU - Jusic, Amela
AU - Thomas, Pınar Buket
AU - Wettinger, Stephanie Bezzina
AU - Doğan, Soner
AU - Farrugia, Rosienne
AU - Gaetano, Carlo
AU - Tuna, Bilge Güvenç
AU - Pinet, Florence
AU - Robinson, Emma L.
AU - Tual-Chalot, Simon
AU - Stellos, Konstantinos
AU - Devaux, Yvan
AU - on behalf of EU-CardioRNA COST Action CA17129
N1 - Funding Information:
This article is based upon work from EU-CardioRNA COST Action CA17129 (www.cardiorna.eu) supported by COST (European Cooperation in Science and Technology). AJ is funded by the European Union's Horizon 2020 research and innovation programme under the Marie Sk?odowska-Curie Actions grant agreement 893435. CG is funded by ?Progetto IMMUNHUB Regione Lombardia? and ?Progetto di rete Ageing IRCCS: progetto IRMA; progetto SIRI?. FP has received a grant by the French Government, managed by the National Research Agency (ANR) under the program ?Investissements d'avenir? with the reference ANR-16-RHUS-0003. ELR is funded by an American Heart Association postdoctoral fellowship (AHA Award Number: 829504). YD is funded by the EU Horizon 2020 project COVIRNA (Grant Agreement # 101016072), the National Research Fund (grants # C14/BM/8225223, C17/BM/11613033 and COVID-19/2020-1/14719577/miRCOVID), the Ministry of Higher Education and Research, and the Heart Foundation-Daniel Wagner of Luxembourg. KS is supported by grants from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (MODVASC, grant agreement No 759248) and the German Research Foundation DFG (SFB834 B12, project number 75732319). STC is supported by a grant from the British Society for Research on Ageing. FP has filed and licensed patents on noncoding RNAs. YD holds patents related to diagnostic and therapeutic applications of RNAs. AJ: Conceptualization, Writing, editing, Visualization. PBT: Writing, editing, critical comments. SBW: Writing, editing, critical comments. SD: Writing, editing, critical comments. RF: Writing, editing, critical comments. CG: Writing, editing, critical comments. BGT: Writing, editing, critical comments. FP: Writing, editing, critical comments. ELR: Writing, editing, critical comments. STC: Literature research, writing and editing. KS: Conceptualization, Writing and editing. YD: Conceptualization, Writing ? review & editing. All authors read and approved the final manuscript.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/5
Y1 - 2022/5
N2 - Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.
AB - Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.
KW - Ageing
KW - Cardiovascular disease
KW - Inflammageing
KW - Noncoding RNAs
UR - http://www.scopus.com/inward/record.url?scp=85126992547&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/35338919
U2 - 10.1016/j.arr.2022.101610
DO - 10.1016/j.arr.2022.101610
M3 - Review article
C2 - 35338919
AN - SCOPUS:85126992547
SN - 1568-1637
VL - 77
JO - Ageing Research Reviews
JF - Ageing Research Reviews
M1 - 101610
ER -