TY - JOUR
T1 - Non-SCFA microbial metabolites associated with fiber fermentation and host health
AU - Grant, Erica T.
AU - De Franco, Hélène
AU - Desai, Mahesh S.
N1 - Acknowledgments
We thank the Luxembourg National Research Fund (FNR) for their support through CORE grants (C15/BM/10318186 and C18/BM/12585940) and a BRIDGES grant (22/17426243) to M.S.D.; E.T.G. was supported by the FNR BRIDGES grant (22/17426243) and H.D. was supported by an FNR Industrial Fellowship grant (16649117).
Publisher Copyright:
© 2024 The Author(s)
PY - 2025/1
Y1 - 2025/1
N2 - Dietary fiber is degraded by commensal gut microbes to yield host-beneficial short-chain fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for other microbial metabolites in shaping host health. In this review we summarize recent findings from dietary fiber intervention studies describing health impacts attributed to microbial metabolites other than SCFAs, particularly secondary bile acids (2°BAs), aromatic amino acid derivatives, neurotransmitters, and B vitamins. We also discuss shifts in microbial metabolism occurring through altered maternal dietary fiber intake and agricultural practices, which warrant further investigation. To optimize the health benefits of dietary fibers, it is essential to survey a range of metabolites and adapt recommendations on a personalized basis, according to the different functional aspects of the microbiome.
AB - Dietary fiber is degraded by commensal gut microbes to yield host-beneficial short-chain fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for other microbial metabolites in shaping host health. In this review we summarize recent findings from dietary fiber intervention studies describing health impacts attributed to microbial metabolites other than SCFAs, particularly secondary bile acids (2°BAs), aromatic amino acid derivatives, neurotransmitters, and B vitamins. We also discuss shifts in microbial metabolism occurring through altered maternal dietary fiber intake and agricultural practices, which warrant further investigation. To optimize the health benefits of dietary fibers, it is essential to survey a range of metabolites and adapt recommendations on a personalized basis, according to the different functional aspects of the microbiome.
KW - dietary fiber
KW - fermentation
KW - microbial metabolites
KW - non-SCFAs
KW - personalized nutrition
KW - Fermentation/physiology
KW - Dietary Fiber/metabolism
KW - Animals
KW - Humans
KW - Gastrointestinal Microbiome/physiology
KW - Fatty Acids, Volatile/metabolism
KW - Bile Acids and Salts/metabolism
UR - http://www.scopus.com/inward/record.url?scp=85198114053&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/38991905/
U2 - 10.1016/j.tem.2024.06.009
DO - 10.1016/j.tem.2024.06.009
M3 - Review article
C2 - 38991905
AN - SCOPUS:85198114053
SN - 1043-2760
VL - 36
SP - 70
EP - 82
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 1
ER -