@article{83c36bd3f1054c478118c5b6b04adf4a,
title = "Non-coding RNAs and exercise: Pathophysiological role and clinical application in the cardiovascular system",
abstract = "There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death worldwide. Despite the benefits of exercise, the intricacies of their underlying molecular mechanisms remain largely unknown. Non-coding RNAs (ncRNAs) have been recognized as a major regulatory network governing gene expression in several physiological processes and appeared as pivotal modulators in a myriad of cardiovascular processes under physiological and pathological conditions. However, little is known about ncRNA expression and role in response to exercise. Revealing the molecular components and mechanisms of the link between exercise and health outcomes will catalyse discoveries of new biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed.",
author = "Gomes, {Clarissa P.C.} and {de Gonzalo-Calvo}, David and Rocio Toro and Tiago Fernandes and Daniel Theisen and Wang, {Da Zhi} and Yvan Devaux and {on behalf of the CardiolincTM network}",
note = "Funding Information: National Research Fund [grant number INTER/EUROSTARS/15/10282117 (to C.P.C.G.)]; the Ministerio de Econom{\'i}a y Com-petitividad [grant number IJCI-2016-29393 (to D.d.G.C.)]; the CIBER Cardiovascular, which is an Instituto de Salud Carlos III Project [grant number CB16/11/00403 (to D.d.G.C.)]; the Fundaci{\'o}n P{\'u}blica Andaluza Progreso y Salud para la Financiaci{\'o}n de la I+i Biom{\'e}dica y en Ciencias de las Salud en Andalucia [grant number PI-0011/2014 (to D.d.G.C.)]; the Fundac¸ {\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (FAPESP) [grant number 2017/04899-9 (to F.P.)]; the NIH grant, U.S.A. [grant numbers HL085635, HL116919 (to D.-Z.W.)]; the Ministry of Higher Education and Research (to D.T.); the Ministry of Sports of Luxembourg (to D.T.); the National Research Fund [grant number INTER/EUROSTARS/15/10282117 (to Y.D.)]; and the Ministry of Higher Education and Research of Luxembourg (to Y.D.). Funding Information: C.P.C.G., D.d.G.-C., D.-Z.W. and Y.D. are members of the CardiolincTM network (www.cardiolinc.org).National Research Fund [grant number INTER/EUROSTARS/15/10282117 (to C.P.C.G.)]; the Ministerio de Econom?a y Competitividad [grant number IJCI-2016-29393 (to D.d.G.C.)]; the CIBER Cardiovascular, which is an Instituto de Salud Carlos III Project [grant number CB16/11/00403 (to D.d.G.C.)]; the Fundaci?n Publica Andaluza Progreso y Salud para la Financiaci?n de la I+i Biom?dica y en Ciencias de las Salud en Andalucia [grant number PI-0011/2014 (to D.d.G.C.)]; the Funda??o de Amparo a Pesquisa do Estado de S?o Paulo (FAPESP) [grant number 2017/04899-9 (to F.P.)]; the NIH grant, U.S.A. [grant numbers HL085635, HL116919 (to D.-Z.W.)]; the Ministry of Higher Education and Research (to D.T.); the Ministry of Sports of Luxembourg (to D.T.); the National Research Fund [grant number INTER/EUROSTARS/15/10282117 (to Y.D.)]; and the Ministry of Higher Education and Research of Luxembourg (to Y.D.) Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = may,
day = "1",
doi = "10.1042/CS20171463",
language = "English",
volume = "132",
pages = "925--942",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd",
number = "9",
}