Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress

Annalisa Dorio; Claudia Cerella; Milena De Nicola; Maria D'Alessio; Giampiero Gualandi; Lina Ghibelli

doi:10.1196/annals.1387.067

Non-apoptogenic Ca²⁺-related extrusion of mitochondria in anoxia/reoxygenation stress

Annalisa Dorio, Claudia Cerella, Milena De Nicola, Maria D'Alessio, Giampiero Gualandi, Lina Ghibelli^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

9 Citations (Scopus)

Abstract

Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca²⁺ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.

Original language	English
Title of host publication	Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion
Subtitle of host publication	Fifth International Conference
Publisher	Blackwell Publishing Inc.
Pages	512-515
Number of pages	4
ISBN (Print)	1573316490, 9781573316491
DOIs	https://doi.org/10.1196/annals.1387.067
Publication status	Published - Mar 2007
Externally published	Yes

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1099
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Anoxia
Apoptosis
Calcium
Mitochondria
Reoxygenation

Access to Document

10.1196/annals.1387.067

Cite this

Dorio, A., Cerella, C., De Nicola, M., D'Alessio, M., Gualandi, G., & Ghibelli, L. (2007). Non-apoptogenic Ca²⁺-related extrusion of mitochondria in anoxia/reoxygenation stress. In Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference (pp. 512-515). (Annals of the New York Academy of Sciences; Vol. 1099). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1387.067

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title = "Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress",

abstract = "Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca2+ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.",

keywords = "Anoxia, Apoptosis, Calcium, Mitochondria, Reoxygenation",

author = "Annalisa Dorio and Claudia Cerella and {De Nicola}, Milena and Maria D'Alessio and Giampiero Gualandi and Lina Ghibelli",

year = "2007",

month = mar,

doi = "10.1196/annals.1387.067",

language = "English",

isbn = "1573316490",

series = "Annals of the New York Academy of Sciences",

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Dorio, A, Cerella, C, De Nicola, M, D'Alessio, M, Gualandi, G & Ghibelli, L 2007, Non-apoptogenic Ca²⁺-related extrusion of mitochondria in anoxia/reoxygenation stress. in Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference. Annals of the New York Academy of Sciences, vol. 1099, Blackwell Publishing Inc., pp. 512-515. https://doi.org/10.1196/annals.1387.067

Non-apoptogenic Ca²⁺-related extrusion of mitochondria in anoxia/reoxygenation stress. / Dorio, Annalisa; Cerella, Claudia; De Nicola, Milena et al.
Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference. Blackwell Publishing Inc., 2007. p. 512-515 (Annals of the New York Academy of Sciences; Vol. 1099).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress

AU - Dorio, Annalisa

AU - Cerella, Claudia

AU - De Nicola, Milena

AU - D'Alessio, Maria

AU - Gualandi, Giampiero

AU - Ghibelli, Lina

PY - 2007/3

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N2 - Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca2+ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.

AB - Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca2+ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.

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KW - Apoptosis

KW - Calcium

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KW - Reoxygenation

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M3 - Conference contribution

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Dorio A, Cerella C, De Nicola M, D'Alessio M, Gualandi G, Ghibelli L. Non-apoptogenic Ca²⁺-related extrusion of mitochondria in anoxia/reoxygenation stress. In Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference. Blackwell Publishing Inc. 2007. p. 512-515. (Annals of the New York Academy of Sciences). doi: 10.1196/annals.1387.067