No interaction between polymorphisms related to vitamin A metabolism and vitamin A intake in relation to colorectal cancer in a prospective Danish cohort

Vibeke Andersen; Ulrich Halekoh; Torsten Bohn; Anne Tjønneland; Ulla Vogel; Tine Iskov Kopp

doi:10.3390/nu11061428

No interaction between polymorphisms related to vitamin A metabolism and vitamin A intake in relation to colorectal cancer in a prospective Danish cohort

Vibeke Andersen^*, Ulrich Halekoh, Torsten Bohn, Anne Tjønneland, Ulla Vogel, Tine Iskov Kopp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Although vitamin A is essential for gut immune cell trafficking (paramount for the intestinal immune system), epidemiological studies on the role of vitamin A in colorectal cancer (CRC) aetiology are conflicting. By using functional polymorphisms, gene–environment (GxE) interaction analyses may identify the biological effects (or “mechanism of action”) of environmental factors on CRC aetiology. Potential interactions between dietary or supplemental vitamin A intake and genetic variation in the vitamin A metabolic pathway genes related to risk of CRC were studied. We used a nested case-cohort design within the Danish “Diet, Cancer and Health” cohort, with prospectively collected lifestyle information from 57,053 participants, and the Cox proportional hazard models and likelihood ratio test. No statistically significant associations between the selected polymorphisms and CRC, and no statistically significant interactions between vitamin A intake and the polymorphisms were found. In conclusion, no support of an involvement of vitamin A in CRC aetiology was found.

Original language	English
Article number	1428
Journal	Nutrients
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/nu11061428
Publication status	Published - Jun 2019

Keywords

Candidate gene
Diet
Gene-environment interaction
Immune system
Pro-vitamin A-carotenoids
Retinol
Vitamin A
Western-style diet

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@article{36f5961178e44e55ad40a9870874b782,

title = "No interaction between polymorphisms related to vitamin A metabolism and vitamin A intake in relation to colorectal cancer in a prospective Danish cohort",

abstract = "Although vitamin A is essential for gut immune cell trafficking (paramount for the intestinal immune system), epidemiological studies on the role of vitamin A in colorectal cancer (CRC) aetiology are conflicting. By using functional polymorphisms, gene–environment (GxE) interaction analyses may identify the biological effects (or “mechanism of action”) of environmental factors on CRC aetiology. Potential interactions between dietary or supplemental vitamin A intake and genetic variation in the vitamin A metabolic pathway genes related to risk of CRC were studied. We used a nested case-cohort design within the Danish “Diet, Cancer and Health” cohort, with prospectively collected lifestyle information from 57,053 participants, and the Cox proportional hazard models and likelihood ratio test. No statistically significant associations between the selected polymorphisms and CRC, and no statistically significant interactions between vitamin A intake and the polymorphisms were found. In conclusion, no support of an involvement of vitamin A in CRC aetiology was found.",

keywords = "Candidate gene, Diet, Gene-environment interaction, Immune system, Pro-vitamin A-carotenoids, Retinol, Vitamin A, Western-style diet",

author = "Vibeke Andersen and Ulrich Halekoh and Torsten Bohn and Anne Tj{\o}nneland and Ulla Vogel and Kopp, {Tine Iskov}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jun,

doi = "10.3390/nu11061428",

language = "English",

volume = "11",

journal = "Nutrients",

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T1 - No interaction between polymorphisms related to vitamin A metabolism and vitamin A intake in relation to colorectal cancer in a prospective Danish cohort

AU - Andersen, Vibeke

AU - Halekoh, Ulrich

AU - Bohn, Torsten

AU - Tjønneland, Anne

AU - Vogel, Ulla

AU - Kopp, Tine Iskov

PY - 2019/6

Y1 - 2019/6

N2 - Although vitamin A is essential for gut immune cell trafficking (paramount for the intestinal immune system), epidemiological studies on the role of vitamin A in colorectal cancer (CRC) aetiology are conflicting. By using functional polymorphisms, gene–environment (GxE) interaction analyses may identify the biological effects (or “mechanism of action”) of environmental factors on CRC aetiology. Potential interactions between dietary or supplemental vitamin A intake and genetic variation in the vitamin A metabolic pathway genes related to risk of CRC were studied. We used a nested case-cohort design within the Danish “Diet, Cancer and Health” cohort, with prospectively collected lifestyle information from 57,053 participants, and the Cox proportional hazard models and likelihood ratio test. No statistically significant associations between the selected polymorphisms and CRC, and no statistically significant interactions between vitamin A intake and the polymorphisms were found. In conclusion, no support of an involvement of vitamin A in CRC aetiology was found.

AB - Although vitamin A is essential for gut immune cell trafficking (paramount for the intestinal immune system), epidemiological studies on the role of vitamin A in colorectal cancer (CRC) aetiology are conflicting. By using functional polymorphisms, gene–environment (GxE) interaction analyses may identify the biological effects (or “mechanism of action”) of environmental factors on CRC aetiology. Potential interactions between dietary or supplemental vitamin A intake and genetic variation in the vitamin A metabolic pathway genes related to risk of CRC were studied. We used a nested case-cohort design within the Danish “Diet, Cancer and Health” cohort, with prospectively collected lifestyle information from 57,053 participants, and the Cox proportional hazard models and likelihood ratio test. No statistically significant associations between the selected polymorphisms and CRC, and no statistically significant interactions between vitamin A intake and the polymorphisms were found. In conclusion, no support of an involvement of vitamin A in CRC aetiology was found.

KW - Candidate gene

KW - Diet

KW - Gene-environment interaction

KW - Immune system

KW - Pro-vitamin A-carotenoids

KW - Retinol

KW - Vitamin A

KW - Western-style diet

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U2 - 10.3390/nu11061428

DO - 10.3390/nu11061428

M3 - Article

C2 - 31242605

AN - SCOPUS:85068927325

SN - 2072-6643

VL - 11

JO - Nutrients

JF - Nutrients

IS - 6

M1 - 1428

ER -

No interaction between polymorphisms related to vitamin A metabolism and vitamin A intake in relation to colorectal cancer in a prospective Danish cohort

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Keywords

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