NK cells in autoimmune and inflammatory diseases

Nicolas Schleinitz, Nassim Dali-Youcef, Jean Robert Harle, Jacques Zimmer, Emmanuel Andres*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    The evidence of NK cell implication in human diseases has initially been shown for antiviral immunity and tumor surveillance. Nowadays, increased attention is being paid to the aspect of NK cells and innate immunity in studies on autoimmune diseases. However, despite a growing knowledge on NK cell function and regulation, their role in human autoimmune disease still remains controversial. In animal models, studies of NK cells have shown conflicting results toward a disease-promoting or disease-protective role. Similarly, in human diseases, available data suggest an unequivocal role of NK cells. Yet, the understanding of NK cell implication in human diseases is far from being achieved. We review here the current knowledge on NK cell biology in human autoimmune and inflammatory diseases and discuss their possible mechanisms of action in these complex pathologies.

    Original languageEnglish
    Title of host publicationNatural Killer Cells
    Subtitle of host publicationAt the Forefront of Modern Immunology
    PublisherSpringer Berlin Heidelberg
    Number of pages14
    ISBN (Print)9783642023088
    Publication statusPublished - 2010


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