TY - JOUR
T1 - New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project
AU - Snapkow, Igor
AU - Smith, Nicola M.
AU - Arnesdotter, Emma
AU - Beekmann, Karsten
AU - Blanc, Etienne B.
AU - Braeuning, Albert
AU - Corsini, Emanuela
AU - Sollner Dolenc, Marija
AU - Duivenvoorde, Loes P.M.
AU - Sundstøl Eriksen, Gunnar
AU - Franko, Nina
AU - Galbiati, Valentina
AU - Gostner, Johanna M.
AU - Grova, Nathalie
AU - Gutleb, Arno C.
AU - Hargitai, Rita
AU - Janssen, Aafke W.F.
AU - Krapf, Solveig A.
AU - Lindeman, Birgitte
AU - Lumniczky, Katalin
AU - Maddalon, Ambra
AU - Mollerup, Steen
AU - Parráková, Lucia
AU - Pierzchalski, Arkadiusz
AU - Pieters, Raymond H.H.
AU - Silva, Maria J.
AU - Solhaug, Anita
AU - Staal, Yvonne C.M.
AU - Straumfors, Anne
AU - Szatmári, Tünde
AU - Turner, Jonathan D.
AU - Vandebriel, Rob J.
AU - Zenclussen, Ana Claudia
AU - Barouki, Robert
N1 - Publisher Copyright:
Copyright © 2024 Snapkow, Smith, Arnesdotter, Beekmann, Blanc, Braeuning, Corsini, Sollner Dolenc, Duivenvoorde, Sundstøl Eriksen, Franko, Galbiati, Gostner, Grova, Gutleb, Hargitai, Janssen, Krapf, Lindeman, Lumniczky, Maddalon, Mollerup, Parráková, Pierzchalski, Pieters, Silva, Solhaug, Staal, Straumfors, Szatmári, Turner, Vandebriel, Zenclussen and Barouki.
PY - 2024/4/9
Y1 - 2024/4/9
N2 - As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immunotoxicity of chemicals relies heavily on rodent models and a limited number of Organisation for Economic Co-operation and Development (OECD) test guidelines, which only capture a fraction of potential toxic properties. Due to this limitation, various authorities, including the World Health Organization and the European Food Safety Authority have highlighted the need for the development of novel approaches without the use of animals for immunotoxicity testing of chemicals. In this paper, we present a concise overview of ongoing efforts dedicated to developing and standardizing methodologies for a comprehensive characterization of the immunotoxic effects of chemicals, which are performed under the EU-funded Partnership for the Assessment of Risk from Chemicals (PARC).
AB - As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immunotoxicity of chemicals relies heavily on rodent models and a limited number of Organisation for Economic Co-operation and Development (OECD) test guidelines, which only capture a fraction of potential toxic properties. Due to this limitation, various authorities, including the World Health Organization and the European Food Safety Authority have highlighted the need for the development of novel approaches without the use of animals for immunotoxicity testing of chemicals. In this paper, we present a concise overview of ongoing efforts dedicated to developing and standardizing methodologies for a comprehensive characterization of the immunotoxic effects of chemicals, which are performed under the EU-funded Partnership for the Assessment of Risk from Chemicals (PARC).
KW - chemical toxicology
KW - immunosuppression
KW - immunotoxicology
KW - NAMs
KW - new approach methodologies
KW - PARC
KW - regulatory toxicology
UR - http://www.scopus.com/inward/record.url?scp=85191031759&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/38654939
U2 - 10.3389/ftox.2024.1339104
DO - 10.3389/ftox.2024.1339104
M3 - Review article
C2 - 38654939
AN - SCOPUS:85191031759
SN - 2673-3080
VL - 6
JO - Frontiers in Toxicology
JF - Frontiers in Toxicology
M1 - 1339104
ER -