Neutralizing B cell response in measles

Fabienne B. Bouche, Oliver T. Ertl, Claude P. Muller*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

76 Citations (Scopus)

Abstract

Co-evolving mechanisms of immune clearance and of immune suppression are among the hallmarks of measles. B cells are major targets cells of measles virus (MV) infection. Virus interactions with B cells result both in immune suppression and a vigorous antibody response. Although antibodies fully protect against (re)infection, their importance during the disease and in the presence of a potent cellular response is less well understood. Specific serum IgM appears with onset of rash and confirms clinical diagnosis. After isotype switching, IgG1 develops and confers life-long protection. The most abundant antibodies are specific for the nucleoprotein, but neutralizing and protective antibodies are solely directed against the two surface glycoproteins, the hemagglutinin and the fusion protein. Major neutralizing epitopes have been mapped mainly on the hemagglutinin protein with monoclonal antibodies, producing an increasingly comprehensive map of functional domains.

Original languageEnglish
Pages (from-to)451-471
Number of pages21
JournalViral Immunology
Volume15
Issue number3
DOIs
Publication statusPublished - 2002
Externally publishedYes

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