Near full-length characterization and population dynamics of the human immunodeficiency virus type i circulating recombinant form 42 (CRF42-BF) in Luxembourg

Daniel Struck; François Roman; Sébastien De Landtsheer; Jean Yves Servais; Christine Lambert; Cécile Masquelier; Véronique Venard; Jean Ruelle; Monique Nijhuis; Jean Claude Schmit; Carole Seguin-Devaux

doi:10.1089/aid.2014.0364

Near full-length characterization and population dynamics of the human immunodeficiency virus type i circulating recombinant form 42 (CRF42-BF) in Luxembourg

Daniel Struck^*, François Roman, Sébastien De Landtsheer, Jean Yves Servais, Christine Lambert, Cécile Masquelier, Véronique Venard, Jean Ruelle, Monique Nijhuis, Jean Claude Schmit, Carole Seguin-Devaux

^*Corresponding author for this work

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Abstract

A new recombinant form representing a mosaic of HIV-1 subtype B and F1 and designated as CRF42-BF was identified in Luxembourg. We confirmed the inedited nature of CRF42-BF by near full-length genome characterization and retrieved a possible ancestor originating from Brazil. The demographic history of CRF42-BF in Luxembourg using Bayesian coalescent-based methods was investigated. The exponential phase of the logistic growth happened in a very short time period of approximately 5 months associated with a high mean rate of population growth of 15.02 new infections per year. However, CRF42-BF was not characterized by either a higher ex vivo replication capacity in peripheral blood mononuclear cells (PBMCs) or a higher ex vivo transmission efficiency from monocyte-derived dendritic cells to PBMCs as compared to B and F1 viruses. These data do not support a high pathogenic potential of CFR42-BF but rather an initial bursting spread of the recombinant probably due to a more favorable transmission route.

Original language	English
Pages (from-to)	554-558
Number of pages	5
Journal	AIDS Research and Human Retroviruses
Volume	31
Issue number	5
DOIs	https://doi.org/10.1089/aid.2014.0364
Publication status	Published - 1 May 2015

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Struck, D., Roman, F., De Landtsheer, S., Servais, J. Y., Lambert, C., Masquelier, C., Venard, V., Ruelle, J., Nijhuis, M., Schmit, J. C., & Seguin-Devaux, C. (2015). Near full-length characterization and population dynamics of the human immunodeficiency virus type i circulating recombinant form 42 (CRF42-BF) in Luxembourg. AIDS Research and Human Retroviruses, 31(5), 554-558. https://doi.org/10.1089/aid.2014.0364

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title = "Near full-length characterization and population dynamics of the human immunodeficiency virus type i circulating recombinant form 42 (CRF42-BF) in Luxembourg",

abstract = "A new recombinant form representing a mosaic of HIV-1 subtype B and F1 and designated as CRF42-BF was identified in Luxembourg. We confirmed the inedited nature of CRF42-BF by near full-length genome characterization and retrieved a possible ancestor originating from Brazil. The demographic history of CRF42-BF in Luxembourg using Bayesian coalescent-based methods was investigated. The exponential phase of the logistic growth happened in a very short time period of approximately 5 months associated with a high mean rate of population growth of 15.02 new infections per year. However, CRF42-BF was not characterized by either a higher ex vivo replication capacity in peripheral blood mononuclear cells (PBMCs) or a higher ex vivo transmission efficiency from monocyte-derived dendritic cells to PBMCs as compared to B and F1 viruses. These data do not support a high pathogenic potential of CFR42-BF but rather an initial bursting spread of the recombinant probably due to a more favorable transmission route.",

author = "Daniel Struck and Fran{\c c}ois Roman and {De Landtsheer}, S{\'e}bastien and Servais, {Jean Yves} and Christine Lambert and C{\'e}cile Masquelier and V{\'e}ronique Venard and Jean Ruelle and Monique Nijhuis and Schmit, {Jean Claude} and Carole Seguin-Devaux",

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Struck, D, Roman, F, De Landtsheer, S, Servais, JY, Lambert, C, Masquelier, C, Venard, V, Ruelle, J, Nijhuis, M, Schmit, JC & Seguin-Devaux, C 2015, 'Near full-length characterization and population dynamics of the human immunodeficiency virus type i circulating recombinant form 42 (CRF42-BF) in Luxembourg', AIDS Research and Human Retroviruses, vol. 31, no. 5, pp. 554-558. https://doi.org/10.1089/aid.2014.0364

Near full-length characterization and population dynamics of the human immunodeficiency virus type i circulating recombinant form 42 (CRF42-BF) in Luxembourg. / Struck, Daniel; Roman, François; De Landtsheer, Sébastien et al.
In: AIDS Research and Human Retroviruses, Vol. 31, No. 5, 01.05.2015, p. 554-558.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Struck, Daniel

AU - Roman, François

AU - De Landtsheer, Sébastien

AU - Servais, Jean Yves

AU - Lambert, Christine

AU - Masquelier, Cécile

AU - Venard, Véronique

AU - Ruelle, Jean

AU - Nijhuis, Monique

AU - Schmit, Jean Claude

AU - Seguin-Devaux, Carole

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Near full-length characterization and population dynamics of the human immunodeficiency virus type i circulating recombinant form 42 (CRF42-BF) in Luxembourg

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