Navigating the path of reproducibility in microRNA-based biomarker research with ring trials

Miron Sopić*, Yvan Devaux, David De Gonzalo-Calvo*, AtheroNET COST Action CA21153

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The development of microRNA (miRNA)-based biomarkers has gained significant attention due to their potential diagnostic, prognostic and therapeutic applications. However, the reproducibility of miRNA biomarker research faces unique challenges, primarily due to the influence of pre-analytical and analytical factors. The absence of standardized procedures contributes to inconsistencies across studies, alongside challenges in reference gene selection, data analysis methods and miRNA profiling platforms. Inter-laboratory comparison trials, or ring trials, offer a strategic approach to address technical and biological variability in miRNA biomarker studies. These trials promote standardization, identify sources of variability and strengthen the correlation between miRNAs and clinical outcomes. Despite their underutilization in miRNA biomarker research, ring trials represent a valuable tool for enhancing reproducibility and expediting the translation of miRNA-based biomarkers into clinical applications.

Original languageEnglish
Pages (from-to)2393-2397
Number of pages5
JournalClinical Chemistry and Laboratory Medicine
Volume62
Issue number12
Early online date16 May 2024
DOIs
Publication statusPublished - 26 Nov 2024

Keywords

  • biomarker
  • microRNA
  • ring trial
  • MicroRNAs/genetics
  • Reproducibility of Results
  • Humans
  • Biomarkers/analysis

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