TY - JOUR
T1 - Navigating the metabolic landscape of regulatory T cells
T2 - from autoimmune diseases to tumor microenvironments
AU - Härm, Janika
AU - Fan, Yu Tong
AU - Brenner, Dirk
N1 - Funding:
D.B. is supported by the Luxembourg National Research Fund (FNR)-CORE
grant (C21/BM/15796788), D.B., J.H. Y.T.F. by the FNR-PRIDE programs
(NEXTIMMUNE2/PRIDE21/16749720; i2TRON/PRIDE19/4254520).
Publisher Copyright:
© 2024 The Authors
PY - 2024/12/12
Y1 - 2024/12/12
N2 - Regulatory T cells (Tregs) are essential for maintaining immune homeostasis, playing crucial roles in modulating autoimmune conditions and contributing to the suppressive tumor microenvironment. Their cellular metabolism governs their generation, stability, proliferation, and suppressive function. Enhancing Treg metabolism to boost their suppressive function offers promising therapeutic potential for alleviating inflammatory symptoms in autoimmune diseases. Conversely, inhibiting Treg metabolism to reduce their suppressive function can enhance the efficacy of traditional immunotherapy in cancer patients. This review explores recent advances in targeting Treg metabolism in autoimmune diseases and the metabolic adaptations of Tregs within the tumor microenvironment that increase their immunosuppressive function.
AB - Regulatory T cells (Tregs) are essential for maintaining immune homeostasis, playing crucial roles in modulating autoimmune conditions and contributing to the suppressive tumor microenvironment. Their cellular metabolism governs their generation, stability, proliferation, and suppressive function. Enhancing Treg metabolism to boost their suppressive function offers promising therapeutic potential for alleviating inflammatory symptoms in autoimmune diseases. Conversely, inhibiting Treg metabolism to reduce their suppressive function can enhance the efficacy of traditional immunotherapy in cancer patients. This review explores recent advances in targeting Treg metabolism in autoimmune diseases and the metabolic adaptations of Tregs within the tumor microenvironment that increase their immunosuppressive function.
UR - http://www.scopus.com/inward/record.url?scp=85211450356&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/39674060/
U2 - 10.1016/j.coi.2024.102511
DO - 10.1016/j.coi.2024.102511
M3 - Review article
C2 - 39674060
AN - SCOPUS:85211450356
SN - 0952-7915
VL - 92
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
M1 - 102511
ER -