Natural killer cells in atopic and autoimmune diseases of the skin

Dagmar von Bubnoff, Emmanuel Andrès, François Hentges, Thomas Bieber, Tatiana Michel, Jacques Zimmer*

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    67 Citations (Scopus)

    Abstract

    Natural killer (NK) cells are best known for their ability to recognize and kill tumor cells and virally infected cells and for their ability to produce large amounts of some cytokines, such as IFN-γ. Recent research has substantially expanded our view on the function of NK cells in the immune system in health and disease. In addition to the better-studied functions in cancer and autoimmunity, contributions from NK cells to allergies and various skin diseases have emerged. We briefly recount the traditional NK cell functions before focusing on their roles in atopic dermatitis, psoriasis, alopecia areata, and pemphigus vulgaris. Although this field is still developing, strong data are available that indicate NK cell involvement. In patients with allergic diseases, the production of TH2 cytokines by NK cells contributes to the known immune deviation. In patients with psoriasis, their pathophysiologic role seems to be especially the production of IFN-γ. NK cell overactivation can be found in patients with alopecia areata and pemphigus vulgaris. Many details are still unclear; however, we believe that there is solid evidence that NK cells actively participate in a number of diseases that have not been traditionally linked to this type of lymphocyte.

    Original languageEnglish
    Pages (from-to)60-68
    Number of pages9
    JournalJournal of Allergy and Clinical Immunology
    Volume125
    Issue number1-3
    DOIs
    Publication statusPublished - Jan 2010

    Keywords

    • Natural killer cells
    • allergy
    • autoimmunity
    • skin

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