TY - JOUR
T1 - Multiple pesticides in mothers' hair samples and children's measurements at birth
T2 - Results from the French national birth cohort (ELFE)
AU - Béranger, Rémi
AU - Hardy, Emilie M.
AU - Binter, Anne Claire
AU - Charles, Marie Aline
AU - Zaros, Cécile
AU - Appenzeller, Brice M.R.
AU - Chevrier, Cécile
N1 - Funding Information:
The ELFE survey is a joint project between the French Institute for Demographic Studies (INED) and the National Institute of Health and Medical Research (INSERM), in partnership with the French blood transfusion service (Etablissement français du sang, EFS), Santé publique France, the National Institute for Statistics and Economic Studies (INSEE), the Direction générale de la santé (DGS, part of the Ministry of Health and Social Affairs), the Direction générale de la prévention des risques (DGPR, Ministry for the Environment), the Direction de la recherche, des études, de l’évaluation et des statistiques (DREES, Ministry of Health and Social Affairs), the Département des études, de la prospective et des statistiques (DEPS, Ministry of Culture), and the Caisse nationale des allocations familiales (CNAF), with the support of the Ministry of Higher Education and Research and the Institut national de la jeunesse et de l’éducation populaire (INJEP). Via the RECONAI platform, it receives a government grant managed by the National Research Agency under the “ Investissements d'avenir” program ( ANR-11-EQPX-0038 ).
Funding Information:
The authors would like to thank all the participants, midwives, and research assistants who participated in recruiting women and collecting biological samples, and the ELFE team. We also thank J.A. Cahn for editorial assistance. R. B?ranger held a post-doctoral fellowship from the Fondation de France (ref. R15158NN) and was supported by the Fondation Mustela (under the aegis of the Fondation de France). This project was funded by the French Agency for Food, Environmental and Occupational Health & Safety (grant PNR EST-13-138). This grant was overseen by the French Ministry of Agriculture, with financial support from the French Agency for Biodiversity, from taxes on diffuse pollution through the Ecophyto plan. The ELFE survey is a joint project between the French Institute for Demographic Studies (INED) and the National Institute of Health and Medical Research (INSERM), in partnership with the French blood transfusion service (Etablissement fran?ais du sang, EFS), Sant? publique France, the National Institute for Statistics and Economic Studies (INSEE), the Direction g?n?rale de la sant? (DGS, part of the Ministry of Health and Social Affairs), the Direction g?n?rale de la pr?vention des risques (DGPR, Ministry for the Environment), the Direction de la recherche, des ?tudes, de l??valuation et des statistiques (DREES, Ministry of Health and Social Affairs), the D?partement des ?tudes, de la prospective et des statistiques (DEPS, Ministry of Culture), and the Caisse nationale des allocations familiales (CNAF), with the support of the Ministry of Higher Education and Research and the Institut national de la jeunesse et de l??ducation populaire (INJEP). Via the RECONAI platform, it receives a government grant managed by the National Research Agency under the ?Investissements d'avenir? program (ANR-11-EQPX-0038).
Funding Information:
The authors would like to thank all the participants, midwives, and research assistants who participated in recruiting women and collecting biological samples, and the ELFE team. We also thank J.A. Cahn for editorial assistance. R. Béranger held a post-doctoral fellowship from the Fondation de France (ref. R15158NN ) and was supported by the Fondation Mustela (under the aegis of the Fondation de France). This project was funded by the French Agency for Food, Environmental and Occupational Health & Safety (grant PNR EST-13-138 ). This grant was overseen by the French Ministry of Agriculture, with financial support from the French Agency for Biodiversity , from taxes on diffuse pollution through the Ecophyto plan.
Publisher Copyright:
© 2019 Elsevier GmbH
PY - 2020/1
Y1 - 2020/1
N2 - Background: A growing body of studies now suggests that the general population is continuously and ubiquitously exposed to numerous pesticides. However, studies investigating the possible role of environmental exposure to pesticides on fetal growth have focused on a limited set of substances, despite the hundreds of modern pesticides currently available. Aim: To explore the relation between maternal hair concentrations of 64 pesticides and metabolites and their newborns’ measurements at birth, with data from the ELFE French nationwide birth cohort. Methods: We measured 64 compounds (10–100% detection) in bundles of hair 9 cm long collected at birth from 311 women who gave birth in France in 2011. We assessed their associations with birth weight, length, and head circumference, adjusted for potential confounders, and used elastic net regularization to simultaneously select the strongest predictors of measurements at birth. Selected variables were multiply imputed for missing values, and unpenalized estimators were assessed by standard linear regression. Results: We observed statistically significant associations between maternal hair concentrations of seven pesticides or pesticide metabolites and birth measurements (weight: fipronil sulfone; length: TCPy, bitertanol, DEP, and isoproturon; head circumference: tebuconazole and prochloraz). Analyses restricted to boys identified 12 additional compounds: 8 independently associated with birth weight (3Me4NP, DCPMU, DMST, fipronil, mecoprop, propoxur, fenhexamid, and thiabendazole), 2 with birth length (dieldrin and β-endosulfan), and 6 with head circumference (β-endosulfan, β-HCH, fenuron, DCPMU, propoxur, and thiabendazole). Conclusion: Our results suggest that prenatal exposure to 19 pesticides or metabolites from various chemical families may influence measurements at birth. As with any exploratory research findings, results should be interpreted cautiously, until they are replicated or verified by further epidemiological or mechanistic studies.
AB - Background: A growing body of studies now suggests that the general population is continuously and ubiquitously exposed to numerous pesticides. However, studies investigating the possible role of environmental exposure to pesticides on fetal growth have focused on a limited set of substances, despite the hundreds of modern pesticides currently available. Aim: To explore the relation between maternal hair concentrations of 64 pesticides and metabolites and their newborns’ measurements at birth, with data from the ELFE French nationwide birth cohort. Methods: We measured 64 compounds (10–100% detection) in bundles of hair 9 cm long collected at birth from 311 women who gave birth in France in 2011. We assessed their associations with birth weight, length, and head circumference, adjusted for potential confounders, and used elastic net regularization to simultaneously select the strongest predictors of measurements at birth. Selected variables were multiply imputed for missing values, and unpenalized estimators were assessed by standard linear regression. Results: We observed statistically significant associations between maternal hair concentrations of seven pesticides or pesticide metabolites and birth measurements (weight: fipronil sulfone; length: TCPy, bitertanol, DEP, and isoproturon; head circumference: tebuconazole and prochloraz). Analyses restricted to boys identified 12 additional compounds: 8 independently associated with birth weight (3Me4NP, DCPMU, DMST, fipronil, mecoprop, propoxur, fenhexamid, and thiabendazole), 2 with birth length (dieldrin and β-endosulfan), and 6 with head circumference (β-endosulfan, β-HCH, fenuron, DCPMU, propoxur, and thiabendazole). Conclusion: Our results suggest that prenatal exposure to 19 pesticides or metabolites from various chemical families may influence measurements at birth. As with any exploratory research findings, results should be interpreted cautiously, until they are replicated or verified by further epidemiological or mechanistic studies.
KW - Birth weight
KW - Environmental exposure
KW - Fetal development
KW - Maternal exposures
KW - Pesticides
UR - http://www.scopus.com/inward/record.url?scp=85075211509&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pubmed/31708466
U2 - 10.1016/j.ijheh.2019.10.010
DO - 10.1016/j.ijheh.2019.10.010
M3 - Article
C2 - 31708466
AN - SCOPUS:85075211509
SN - 1438-4639
VL - 223
SP - 22
EP - 33
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
IS - 1
ER -